PMID: 11338069May 8, 2001Paper

Ridogrel enemas in distal ulcerative colitis

European Journal of Gastroenterology & Hepatology
J J AuwerdaR J Ouwendijk

Abstract

To evaluate the effect of Ridogrel enemas (Janssen Research Foundation, Beerse, Belgium) on disease activity and mucosal inflammatory mediators in patients with active left-sided ulcerative colitis. Eleven patients with active left-sided ulcerative colitis were evaluated in an open non-placebo-controlled pilot study. All patients were treated with Ridogrel enemas (300 mg/40 ml once daily) over four weeks. A disease activity score based on clinical, endoscopic and histological criteria was obtained before and after treatment with Ridogrel. The concentrations of thromboxane B2 (TxB2), prostaglandin E2 (PGE2), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) were measured in mucosal biopsies before and after treatment. One patient discontinued treatment because of progression of disease, the other ten patients tolerated the Ridogrel enemas well. Mucosal TxB2 concentration decreased significantly in all patients. The mucosal concentrations of the other inflammatory mediators (PGE2, IL-6 and TNF-alpha) were unaltered. The disease score decreased in five patients. However, clinical improvement was not always associated with a decrease in endoscopic and/or histological scores. This pilot study shows that Ridogrel enem...Continue Reading

References

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Citations

Nov 21, 2002·Current Gastroenterology Reports·Russell D Cohen
Dec 24, 2010·Journal of Gastroenterology and Hepatology·Ian Craig Lawrance
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ian Craig Lawrance
Apr 23, 2013·Gastroenterology Research and Practice·Yuan LiuSi-Hua Gao
Mar 1, 2008·Journal of Crohn's & Colitis·S P L TravisUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Aug 10, 2007·Expert Opinion on Investigational Drugs·Laurence Guy HowesCatherine Walker
Oct 24, 2006·Annals of the New York Academy of Sciences·Ossama A HatoumDavid G Binion
Jan 15, 2014·Inflammatory Bowel Diseases·Mahmoud H MosliBarrett G Levesque

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