Rifampicin Alleviates Atopic Dermatitis-Like Response in vivo and in vitro

Biomolecules & Therapeutics
Seung Hyun KimTae Jin Kang

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it was reported that rifampicin has anti-inflammatory and immune-suppressive activities. In this study, we investigated the effect of rifampicin on atopic dermatitis in vivo and in vitro. AD was induced by treatment with 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice. A subset of mice was then treated with rifampicin by oral administration. The severity score and scratching behavior were alleviated in the rifampicin-treated group. Serum immunoglobulin E (IgE) and interleukin-4 (IL-4) levels were also ameliorated in mice treated with rifampicin. We next examined whether rifampicin has anti-atopic activity via suppression of mast cell activation. Rifampicin suppressed the release of β-hexosaminidase and histamine from human mast cell (HMC)-1 cultures stimulated with compound 48/80. Treatment with rifampicin also inhibited secretion of inflammatory mediators, such tumor necrosis factor-α (TNF-α) and prostaglandin D₂ (PGD₂), in mast cells activated by compound 48/80. The mRNA expression of cyclooxygenase 2 (COX-2) was reduced in the ...Continue Reading

References

Dec 1, 1990·Immunology Today·J R GordonS J Galli
Jan 1, 1985·British Journal of Clinical Pharmacology·F L Pearce
Aug 14, 1971·Lancet·B S Nilsson
Jul 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M J Tsai, G F Saunders
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·W WehrliM Staehelin
May 10, 1969·Nature·E di MauroG P Tocchini-Valentini
May 1, 1980·The Journal of Investigative Dermatology·L B Schwartz, K F Austen
Jan 1, 1980·Infection and Immunity·A Bellahsène, A Forsgren
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R L BergmannU Wahn
Aug 10, 1999·The Pediatric Infectious Disease Journal·A M Loeffler
Oct 26, 1999·International Archives of Allergy and Immunology·H SutoC Ra
Dec 21, 2000·Clinical and Experimental Dermatology·R Sidbury, J M Hanifin
Jan 22, 2003·The British Journal of Dermatology·M FurueT Koga
Mar 1, 2003·Clinics in Dermatology·Nikolai Tsankov, Irena Angelova
Mar 3, 2004·The Journal of Clinical Investigation·Donald Y M LeungQutayba A Hamid
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Aug 31, 2004·Journal of Chemotherapy·H M ZiglamR G Finch
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Tse Wen Chang, Yu-Yu Shiung
Oct 22, 2008·Nature Immunology·Janet Kalesnikoff, Stephen J Galli
Jan 8, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seong Keun KimSeong-Beom Lee
Feb 1, 2011·Pflügers Archiv : European journal of physiology·Michael Eisenhut, Helen Wallace
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Tae Ho ChungJin Yeul Ma
Dec 15, 2012·Pharmacological Reports : PR·Weimin WangKeqin Zou
Apr 10, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaohui WangHang Yin
Dec 10, 2014·Biomolecules & Therapeutics·Ji-Wook JungJu-Young Lee
Jul 15, 2015·Biomolecules & Therapeutics·Sung Cil LimTae Jin Kang

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Citations

Mar 7, 2020·Biomolecules & Therapeutics·Annamneedi Venkata PrakashTae Jin Kang
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Kelsey DeFratesXiao Hu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
ELISAs

Software Mentioned

GraphPad Prism

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.