Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic rats.

World Journal of Gastroenterology : WJG
Gemma OdenaR Bartolí

Abstract

To compare rifaximin and insulin-like growth factor (IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal occlusion. Rats with CCl₄-induced cirrhosis with ascites plus portal vein occlusion and controls were randomized into six groups: Cirrhosis; Cirrhosis + IGF-1; Cirrhosis + rifaximin; Controls; Controls + IGF-1; and Controls + rifaximin. An oral glutamine-challenge test was performed, and plasma and cerebral ammonia, glucose, bilirubin, transaminases, endotoxemia, brain water content and ileocecal cultures were measured and liver histology was assessed. Rifaximin treatment significantly reduced bacterial overgrowth and endotoxemia compared with cirrhosis groups, and improved some liver function parameters (bilirubin, alanine aminotransferase and aspartate aminotransferase). These effects were associated with a significant reduction in cerebral water content. Blood and cerebral ammonia levels, and area-under-the-curve values for oral glutamine-challenge tests were similar in rifaximin-treated cirrhotic rats and control group animals. By contrast, IGF-1 administration failed to improve most alterations observed in cirrhosis. By reducing gut bacterial overgrowth, only rifaximin was capable of normali...Continue Reading

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Citations

Feb 1, 2014·Medicina clínica·Rosa M MorillasRamon Planas
Jun 3, 2014·Frontiers in Neuroendocrinology·Farida Sohrabji
Feb 15, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Avinash KumarSrinivasan Dasarathy
Jan 10, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Luigi MelcarneMeritxell Casas
Nov 23, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seung Kak ShinJu Hyun Kim

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