Rifaximin in the management of colonic diverticular disease

Expert Review of Gastroenterology & Hepatology
Giovanni Latella, Carmelo Scarpignato

Abstract

Rifaximin is a rifamycin derivative that acts by inhibiting bacterial RNA synthesis. Since it is virtually unabsorbed after oral administration, its bioavailability within the GI tract is high, with intraluminal and fecal drug concentrations largely exceeding the minimum inhibitory concentration values observed in vitro against a broad spectrum of bacteria, including Gram-positive and Gram-negative bacteria, both aerobes and anaerobes. The GI tract, therefore, represents the primary therapeutic target and the disorders in which intestinal bacteria have a pathogenic role represent the main indication. This is the case with colonic diverticular disease. As a consequence, the broad antibacterial activity of rifaximin appears to be of value in the treatment of this clinical condition. Clinical trials have provided evidence of the substantial benefit of rifaximin in diverticular disease. Indeed, available data show the efficacy of the drug in achieving symptomatic relief in patients with uncomplicated disease. A therapeutic gain of approximately 30%, compared with fiber supplementation only, can be expected after cyclic administration of rifaximin for 12 months. However, its value in the prevention of inflammatory complications of t...Continue Reading

References

Mar 10, 1979·Lancet·J S GearM P Vessey
Nov 1, 1985·The American Journal of Clinical Nutrition·N FisherJ Hardy
Dec 1, 1984·The Journal of Antibiotics·M BrufaniA Segre
Dec 1, 1984·The Journal of Antibiotics·M BrufaniA Vaciago
Feb 7, 1980·The New England Journal of Medicine·T P Almy, D A Howell
Nov 1, 1994·The American Journal of Clinical Nutrition·W H AldooriW C Willett
Jan 1, 1996·Gerontology·M Mac MahonD Coakley
May 16, 1998·The Journal of Nutrition·W H AldooriW C Willett
May 20, 1998·European Journal of Clinical Pharmacology·F RizzelloM Campieri
May 21, 1998·The New England Journal of Medicine·L B FerzocoW Silen
Apr 24, 1999·Diseases of the Colon and Rectum·S SchechterT E Eisenstat
Jul 18, 2000·Antimicrobial Agents and Chemotherapy·Z D JiangH Dupont
Jul 4, 2001·Gastroenterology Clinics of North America·R J FarrellM M Morrin
May 2, 2002·Gastroenterology·Robert S SandlerRobert Rubin
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A TursiR Daffinà
Nov 30, 2002·International Journal of Colorectal Disease·Giovanni LatellaGiuseppe Frieri
Aug 19, 2004·JAMA : the Journal of the American Medical Association·Henry C Lin
Apr 7, 2005·Digestive Diseases and Sciences·Francesco Di MarioAngelo Franzé
Apr 28, 2005·Chemotherapy·Einar Husebye
Apr 28, 2005·Chemotherapy·Carmelo Scarpignato, Iva Pelosini
Apr 28, 2005·Chemotherapy·Z D Jiang, H L DuPont
Apr 28, 2005·Chemotherapy·Michele Di Stefano, Gino Roberto Corazza
Apr 28, 2005·Chemotherapy·Claudio PapiLucio Capurso
May 11, 2005·World Journal of Gastroenterology : WJG·Antonio TursiWalter Elisei
Jun 4, 2005·Alimentary Pharmacology & Therapeutics·S MoriniE Ierardi
Feb 25, 2006·Digestion·Giuseppe FrieriCarmelo Scarpignato
May 4, 2006·Alimentary Pharmacology & Therapeutics·L PetruzzielloG Costamagna
May 24, 2006·World Journal of Gastroenterology : WJG·Martin-H Floch, Jonathan-A White
Jun 3, 2006·Diseases of the Colon and Rectum·Janice RaffertyUNKNOWN Standards Committee of American Society of Colon and Rectal Surgeons
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Fredrik HjernClaes Johansson
Feb 8, 2007·The Annals of Pharmacotherapy·Carol Braun TrapnellDoug K Bettenhausen
Mar 22, 2007·Alimentary Pharmacology & Therapeutics·R D'IncàG C Sturniolo
Apr 6, 2007·Digestive Diseases and Sciences·Giuseppe ComparatoFrancesco Di Mario
Nov 9, 2007·Digestive Diseases and Sciences·Reza KhoshiniMark Pimentel
Nov 29, 2007·Current Opinion in Gastroenterology·Mohamed OthmanHenry C Lin

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Citations

Jul 15, 2015·Nature Reviews. Gastroenterology & Hepatology·Roland H Pfützer, Wolfgang Kruis
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·Ggg DondersD Rezeberga
Oct 16, 2015·Digestive Diseases and Sciences·Eleonora ScaioliDavide Festi
Sep 12, 2015·La Presse médicale·Johann DréanicRomain Coriat
May 17, 2015·Gastroenterología y hepatología·Carla J Gargallo PuyueloAngel Lanas Arbeloa
Feb 3, 2012·Orvosi hetilap·László Lakatos, Péter László Lakatos
Nov 8, 2011·The American Journal of Gastroenterology·Angelo ZulloRoberto Lorenzetti
Sep 14, 2016·Journal of Clinical Gastroenterology·Alberto LuéAngel Lanas
Sep 20, 2012·American Journal of Therapeutics·Josmi JosephSury Anand
Nov 2, 2014·United European Gastroenterology Journal·Rosario CuomoBruno Annibale
Mar 29, 2020·Nature Reviews. Disease Primers·Antonio TursiSilvio Danese
Mar 2, 2021·Gastroenterología y hepatología·David Saavedra-PerezXavier Perez

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