RIG-I in RNA virus recognition

Virology
Alison M Kell, Michael Gale

Abstract

Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition rece...Continue Reading

References

Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Cazenave, O C Uhlenbeck
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerP Palese
Jun 28, 2003·Journal of Virology·Christopher F BaslerAdolfo García-Sastre
Dec 4, 2004·Nature Medicine·Peter Palese
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yueh-Ming LooMichael Gale
Oct 6, 2006·Journal of Virology·Akihiko Komuro, Curt M Horvath
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Oct 20, 2006·Virology·Kay ChildsStephen Goodbourn
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takeshi SaitoMichael Gale
Mar 21, 2007·Cellular and Molecular Life Sciences : CMLS·U SchneiderP Staeheli
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Feb 5, 2008·Molecular Cell·Sheng CuiKarl-Peter Hopfner
Feb 19, 2008·Current Opinion in Immunology·Zhengmao Ye, Jenny Pan-Yun Ting
Aug 16, 2008·Cytokine·Akihiko KomuroCurt M Horvath
Oct 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michaela U GackJae U Jung
Nov 21, 2008·Journal of Virology·K S ChildsS Goodbourn
Jul 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andreas SchmidtSimon Rothenfusser
Jul 25, 2009·Virology·Christina F SpiropoulouSuryaprakash Sambhara
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takashi SatohOsamu Takeuchi
Feb 9, 2010·PLoS Pathogens·Mehul S SutharMichael Gale
Apr 9, 2010·Journal of Innate Immunity·Misao Matsushita
May 21, 2010·Cellular Microbiology·Mirco Schmolke, Adolfo García-Sastre
Jun 29, 2010·Nature Structural & Molecular Biology·Yanli WangDinshaw J Patel

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Citations

Nov 5, 2015·Current Opinion in Immunology·Hiroki Kato, Takashi Fujita
Oct 30, 2016·Current Opinion in Immunology·Yongfen Xu, Jin Zhong
Jul 30, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Keisuke YamamotoShin-Ichi Yokota
Oct 30, 2016·Current Opinion in Virology·Michaela U Gack, Michael S Diamond
Apr 5, 2017·IUBMB Life·Nanhua ChenJianzhong Zhu
Mar 21, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amy E L Stone, Michael J Gale
May 23, 2017·The Journal of General Virology·Preeti ChhabraJan Vinjé
Apr 21, 2018·Annual Review of Immunology·Kwan T ChowYueh-Ming Loo
Sep 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maolin GeJianguo Wu
May 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joris K SprokholtTeunis B H Geijtenbeek
Apr 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Peng PangXiaoyin Chen
Sep 28, 2017·PLoS Pathogens·Sharon K Kuss-DuerkopBeatriz M A Fontoura
Oct 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kwan T ChowMichael Gale
Apr 2, 2019·Bioscience Trends·Kehui LiuHui Wang
Jun 13, 2019·Viral Immunology·Yinuo GuFang Wang
Jul 18, 2019·Cells·Cheung Pang WongTom C Hobman
Oct 7, 2017·Current Medicinal Chemistry·Giulia FreerMauro Pistello
Jan 26, 2020·Journal of Medical Virology·Geng LiJianguo Wu
Apr 24, 2020·Journal of Leukocyte Biology·Pak-Hin Hinson CheungDong-Yan Jin
Feb 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Juan F Burgueño, Maria T Abreu

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Methods Mentioned

BETA
ubiquitination
lavages
deubiquitination

Software Mentioned

RNAfold

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