RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Joris K SprokholtTeunis B H Geijtenbeek

Abstract

Dengue virus (DENV) causes 400 million infections annually and is one of several viruses that can cause viral hemorrhagic fever, which is characterized by uncontrolled immune activation resulting in high fever and internal bleeding. Although the underlying mechanisms are unknown, massive cytokine secretion is thought to be involved. Dendritic cells (DCs) are the main target cells of DENV, and we investigated their role in DENV-induced cytokine production and adaptive immune responses. DENV infection induced DC maturation and secretion of IL-1β, IL-6, and TNF. Inhibition of DENV RNA replication abrogated these responses. Notably, silencing of RNA sensors RIG-I or MDA5 abrogated DC maturation, as well as cytokine responses by DENV-infected DCs. DC maturation was induced by type I IFN responses because inhibition of IFN-α/β receptor signaling abrogated DENV-induced DC maturation. Moreover, DENV infection of DCs resulted in CCL2, CCL3, and CCL4 expression, which was abrogated after RIG-I and MDA5 silencing. DCs play an essential role in TH cell differentiation, and we show that RIG-I and MDA5 triggering by DENV leads to TH1 polarization, which is characterized by high levels of IFN-γ. Notably, cytokines IL-6, TNF, and IFN-γ and che...Continue Reading

References

Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M G NeteaJ W Van der Meer
Apr 2, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·M MarovichJ Mascola
Apr 12, 2003·The Journal of Experimental Medicine·Boonrat TassaneetrithepMary A Marovich
Feb 1, 2005·Journal of Virology·Dupeh R PalmerTimothy Burgess
Jul 8, 2005·Journal of Clinical Microbiology·C R LambethA M de Silva
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wilfred LimAshok Kumar
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Feb 13, 2008·PLoS Pathogens·Joanna L MillerSiamon Gordon
Feb 15, 2008·Current Opinion in Immunology·Osamu Takeuchi, Shizuo Akira
May 23, 2008·Nature·Szu-Ting ChenShie-Liang Hsieh
Jan 13, 2009·Cellular Microbiology·Yi-Ting TsaiChuan-Liang Kao
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michal Caspi TalAkiko Iwasaki
Feb 19, 2010·Journal of Virology·Juan R Rodriguez-MadozAna Fernandez-Sesma
Jan 20, 2011·PLoS Neglected Tropical Diseases·A M A NasirudeenDing Xiang Liu
May 25, 2011·The Journal of Infectious Diseases·Amanda J ChaseJorge L Muñoz-Jordán
Jan 14, 2012·PLoS Pathogens·Alissa M PhamBenjamin R TenOever
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daimon P SimmonsClifford V Harding
Mar 7, 2012·Microbiology and Molecular Biology Reviews : MMBR·Jennifer R TisoncikMichael G Katze
May 23, 2012·Nature Immunology·Hideo NegishiTadatsugu Taniguchi
Oct 24, 2012·Virology·Thaís Moraes da ConceiçãoLuciana Barros de Arruda
Apr 5, 2013·PLoS Pathogens·Juliet MorrisonAdolfo García-Sastre
Apr 9, 2013·Nature·Samir BhattSimon I Hay
Jul 16, 2014·Antiviral Research·Anon Srikiatkhachorn, James F Kelley
Mar 10, 2015·Virology·Alison M Kell, Michael Gale
Oct 16, 2015·Journal of Biomedical Science·Daisy Vanitha JohnGuey Chuen Perng
Jun 14, 2016·Nature Reviews. Immunology·Teunis B H Geijtenbeek, Sonja I Gringhuis

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Citations

Apr 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew M HalpertWilliam K Decker
Mar 1, 2017·Future Virology·Joris SprokholtTeunis Bh Geijtenbeek
Sep 10, 2020·Frontiers in Immunology·Sumbul AfrozNooruddin Khan
Apr 9, 2020·Journal of Biomedical Science·Ayesha WijesingheGathsaurie Neelika Malavige
Jan 11, 2020·Frontiers in Immunology·Martha GschwandtnerKim S Midwood
Dec 20, 2018·Frontiers in Genetics·Clément MazeaudLaurent Chatel-Chaix
Feb 11, 2020·Frontiers in Immunology·Melissa StunnenbergTeunis B H Geijtenbeek
Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·Ting-Jing ShenChiou-Feng Lin
Nov 17, 2020·Frontiers in Immunology·Alfredo E Montes-GómezLeticia Cedillo-Barrón
Feb 27, 2021·Frontiers in Cellular and Infection Microbiology·Ting-Jing ShenChiou-Feng Lin
Jul 6, 2021·European Journal of Immunology·Melissa StunnenbergTeunis B H Geijtenbeek
Aug 28, 2021·Frontiers in Cellular and Infection Microbiology·S Gowri SankarA Alwin Prem Anand

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