Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder.

Psychosomatic Medicine
Irina A StrigoAlan N Simmons

Abstract

To use functional magnetic resonance imaging (fMRI) to examine how shifts in homeostatic state affect anticipatory insular activity in major depressive disorder (MDD). An intact ability to mount preparatory emotional, cognitive, and bodily responses to anticipated environmental change is necessary for adaptive responding. Although abnormal insula activity during aversive anticipation has been observed in individuals with MDD, the extent to which shifts in homeostatic state during anticipation affect insular activity in MDD subjects has not been reported. Cued hot and warm stimuli were delivered as subjects either passively viewed a fixation cross or performed an attentional task during fMRI. The task was designed so that anticipatory brain activation related to the following three types of shifts could be measured: 1) anticipatory shifts in stimulus intensity; 2) anticipatory shifts in cognitive demand; and 3) dual anticipatory shifts (i.e., shifts in both stimulus intensity and cognitive demand). Brain activation related to each of these three contrasts was compared between 15 (12 females) unmedicated subjects with current MDD and 17 (10 females) age- and education-comparable healthy control (HC) subjects. MDD vs. HC subjects ...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D FormanD C Noll
Feb 1, 1995·The British Journal of Clinical Psychology·K MoggR Williams
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Jan 1, 1998·Transplantation Proceedings·M R First
Aug 1, 1998·Journal of Personality and Social Psychology·S LyubomirskyS Nolen-Hoeksema
Jan 23, 1999·Journal of Personality and Social Psychology·R M Wenzlaff, D E Bates
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
Jan 20, 2004·Nature Neuroscience·Hugo D CritchleyRaymond J Dolan
Jul 2, 2004·Nature·Jim Giles
Oct 19, 2004·Psychiatry Research·Jukka M LeppänenJari K Hietanen
Nov 13, 2004·Journal of Personality and Social Psychology·Lisa Feldman BarrettKeith R Aronson
May 10, 2005·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw
Jul 9, 2005·Current Opinion in Neurology·Stefan Wiens
Jul 12, 2005·Psychoneuroendocrinology·Julian F Thayer, Jos F Brosschot
Nov 9, 2005·Trends in Cognitive Sciences·A D Bud Craig
Dec 15, 2005·Journal of Abnormal Psychology·Jonathan RottenbergIan H Gotlib
Aug 26, 2006·The European Journal of Neuroscience·Susanne ErkHenrik Walter
Dec 23, 2006·NeuroImage·Tilmann A KleinMarkus Ullsperger
Jun 20, 2007·Psychological Science·Anson J Whitmer, Marie T Banich
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom JohnstoneRichard J Davidson
Nov 17, 2007·Clinical Psychology Review·Lauren M BylsmaJonathan Rottenberg
Feb 22, 2008·International Journal of Dermatology·Craig G Burkhart, Craig N Burkhart
Jun 27, 2008·Brain : a Journal of Neurology·P KumarJ D Steele
Jul 1, 2008·NeuroImage·Joana V Taylor TavaresWayne C Drevets
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Julian F Thayer, Richard D Lane
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Mar 18, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Kristen SalomonJonathan Rottenberg
Sep 8, 2009·Psychological Medicine·U HerwigL Jäncke

❮ Previous
Next ❯

Citations

Jun 3, 2014·Journal of Affective Disorders·Junya FujinoToshiya Murai
Apr 17, 2012·Neuroscience Letters·Isabella MutschlerIrina A Strigo
Mar 23, 2011·Neuropharmacology·Alan N Simmons, Scott C Matthews
Sep 2, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiu-Li WangQi-Yong Gong
Sep 4, 2016·The Journal of Pain : Official Journal of the American Pain Society·Trevor ThompsonBrendon Stubbs
Nov 5, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David BorsookLino Becerra
May 18, 2019·Expert Review of Neurotherapeutics·Mbemba Jabbi, Charles B Nemeroff
Feb 2, 2019·Personality Neuroscience·Yoed N KenettJohn D Medaglia
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robin L AupperleMartin P Paulus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.