Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients

The Journal of Headache and Pain
Marian Gomez-BeldarrainJuan Carlos Garcıa-Monco

Abstract

Structural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear. Prospective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were assessed. Participants underwent a diffusion-tensor MRI to establish the integrity of white matter tracts of three regions of interest (ROIs) implicated in pain modulation, emotion, cognition and resilience (anterior insula, anterior cingulate gyrus, and uncinate fasciculus). Fifty-two individuals were enrolled: 19 episodic migraine patients, 18 chronic migraine patients, and 15 controls. The analysis of the fractional anisotropy in the ROIs showed that those patients with the poorest prognosis (i.e., those with chronic migraine despite therapy at six months--long-term chronic migraneurs) had a significantly lower fractional anisotropy in the right ROIs. Participants with higher cognitive reserve also had greater fractional anisotropy in the right anterior insula and both cingulate gyri. Multivariate analysis showed a significant association between co...Continue Reading

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Citations

Jul 9, 2016·Expert Review of Neurotherapeutics·Carlo LovatiClaudio Mariani
Mar 13, 2016·The Journal of Headache and Pain·Marian Gomez-BeldarrainJuan Carlos Garcıa-Monco
Dec 1, 2017·Journal of Orthopaedic Surgery and Research·Yasushi WakoSeiji Ohtori
Aug 16, 2017·The Journal of Headache and Pain·Zhiye ChenShengyuan Yu
Sep 12, 2018·Chinese Medical Journal·Zhi-Ye ChenSheng-Yuan Yu
Nov 2, 2019·Cephalalgia : an International Journal of Headache·Álvaro Planchuelo-GómezRodrigo de Luis-García
Sep 22, 2018·The Egyptian Journal of Neurology, Psychiatry and Neurosurgery·Mohamed NegmAlshimaa Asran
Nov 1, 2016·The Journal of Headache and Pain·Zhiye ChenShengyuan Yu
Jan 4, 2020·The Journal of Headache and Pain·Álvaro Planchuelo-GómezRodrigo de Luis-García
Jun 7, 2021·Neuroscience and Biobehavioral Reviews·Anne Margarette S MaalloScott A Holmes
Nov 12, 2021·Frontiers in Psychology·Selma Delgado-GallénGabriele Cattaneo

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Methods Mentioned

BETA
imaging technique

Software Mentioned

FSL FAST FMRIB Automated Segmentation Tool
JHU Matter Tractography Atlas
FSL
TBSS ( Tract - Based Spatial Statistics )
Oxford Centre for MRI of the Brain ( FMRIB ) Software Library ...
Brain Extraction Tool ( BET )
SAS System
FDT ( FMRIB Diffusion Toolbox ) package
TBSS

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