PMID: 9449958Feb 5, 1998Paper

Right heart ischemia: pathophysiology, natural history, and clinical management

Progress in Cardiovascular Diseases
J A Goldstein

Abstract

Right ventricular (RV) ischemia occurs in 50% of patients with acute inferior myocardial infarction, and may result in severe hemodynamic compromise associated with poor clinical outcome. Acute right coronary artery (RCA) occlusion proximal to the RV branches results in right ventricular free wall (RVFW) dysfunction. The ischemic, dyskinetic RVFW exerts mechanically disadvantageous effects on biventricular performance. Depressed RV systolic function leads to a decrease in transpulmonary delivery of left ventricular (LV) preload, resulting in diminished cardiac output. The ischemic right ventricle is stiff, dilated, and volume dependent, resulting in pandiastolic RV dysfunction and septally-mediated alterations in LV compliance, which are exacerbated by elevated intrapericardial pressure. Under these conditions, RV pressure generation and output are dependent on LV-septal contractile contributions, governed by both primary septal contraction and paradoxical septal motion. When the culprit coronary lesion is distal to the right atrial (RA) branches, augmented RA contractility enhances RV performance and optimizes cardiac output. Conversely, more proximal occlusions result in ischemic depression of RA contractility, which impairs ...Continue Reading

References

Nov 1, 1975·The American Journal of Medicine·S H RahimtoolaR M Gunnar
Sep 1, 1992·Catheterization and Cardiovascular Diagnosis·S G Cresci, J A Goldstein
Nov 15, 1991·Journal of the American College of Cardiology·J A GoldsteinJ L Cox
Mar 1, 1990·Journal of the American College of Cardiology·B D RobalinoP L Whitlow
Feb 1, 1990·Circulation·P B Berger, T J Ryan
Aug 1, 1989·The American Journal of Cardiology·J J FergusonR C Pasternak
May 1, 1985·Journal of the American College of Cardiology·M S VeraniA E Raizner
Apr 1, 1987·The Annals of Thoracic Surgery·J M CaralpsO Bonnin
Nov 1, 1986·Journal of the American College of Cardiology·R C WesleyL Belardinelli
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Feb 1, 1974·The American Journal of Cardiology·J N CohnC J Limas
Sep 1, 1968·British Heart Journal·G Farrer-Brown
Aug 1, 1983·Journal of the American College of Cardiology·J A GoldsteinK Chatterjee

❮ Previous
Next ❯

Citations

Feb 5, 2000·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·R PaianoJ Smith-Love
Sep 13, 2002·Journal of the American College of Cardiology·James A Goldstein
Aug 15, 1998·The New England Journal of Medicine·A CohenC Chauvel
Nov 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Luciano Babuin, Allan S Jaffe
Feb 1, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vjekoslav OrozovićRadoslav Romanović
Apr 12, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Branko GligićAndelka Ristić-Andelkov
Oct 19, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Saso RafajlovskiAndelka Ristić-Andelkov
Nov 25, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Saso RafajlovskiGoran Raden
Nov 7, 2012·Pulmonary Circulation·Evan L BrittainTom Disalvo
Aug 3, 2010·The American Journal of Emergency Medicine·Valentina ValentiAndrea Ballotta
Aug 9, 2008·International Journal of Cardiology·Ihab S RamzyMichael Y Henein
Jun 19, 2007·Journal of Clinical Anesthesia·Alice Wood, Karim Bendjelid
Dec 7, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Bei WangLauri Toivonen
Nov 14, 2013·European Heart Journal. Acute Cardiovascular Care·Taku InoharaVenu Menon
Aug 28, 2004·The Milbank Quarterly·Maxwell J Mehlman
Nov 7, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Afonso Celso PereiraValdir Golin
Jun 15, 2018·Expert Review of Cardiovascular Therapy·Arif AlbulushiYiannis S Chatzizisis
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Colleen M FitzpatrickJohn E Baker
Apr 30, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Steven J KernisWilliam W O'Neill
Apr 14, 2018·Circulation·Marvin A KonstamUNKNOWN American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Ca
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carrie E PerlmanLyle F Mockros
Jan 18, 2020·AACN Advanced Critical Care·Cynthia Webner
Aug 17, 1999·Current Opinion in Cardiology·J A Goldstein
Mar 10, 2001·Current Treatment Options in Cardiovascular Medicine·Soo-Teik Lim, James A. Goldstein
Sep 10, 2003·Current Opinion in Cardiology·Francesco PizzutoFrancesco Romeo
Nov 21, 2002·Critical Care Medicine·Jacek A Wojtczak, James E Szalados
Nov 19, 2021·Hormone Molecular Biology and Clinical Investigation·Mustafa Umut SomuncuMurat Can

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

The New England Journal of Medicine
J W Kinch, T J Ryan
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Petri KorhonenLauri Toivonen
© 2021 Meta ULC. All rights reserved