Right isomerism of the brain in inversus viscerum mutant mice.

PloS One
Ryosuke KawakamiIsao Ito

Abstract

Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-D-aspartate receptor (NMDAR) subunit GluRepsilon2 (NR2B) in hippocampal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the epsilon2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.

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Citations

Dec 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yoshiaki ShinoharaRyuichi Shigemoto
Jan 4, 2013·Neurochemical Research·Gonglin HouTi-Fei Yuan
Apr 5, 2013·Nature Communications·Yoshiaki ShinoharaHajime Hirase
Oct 3, 2013·The Journal of Physiology·Marco Capogna
May 8, 2015·Annals of the New York Academy of Sciences·Clyde Francks
May 18, 2011·Biochemical and Biophysical Research Communications·Yoshiaki ShinoharaHajime Hirase
Nov 10, 2009·Journal of the Neurological Sciences·Aya IharaTsutomu Murata
Oct 30, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura N Vandenberg, Michael Levin
Jun 20, 2015·Cardiology in the Young·Rohit S LoombaRobert H Anderson
Sep 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Olivia A ShiptonMichael M Kohl
Sep 23, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mohamady El-GabyOle Paulsen
Jan 1, 2017·Neurobiology of Learning and Memory·Kazuhiro Goto, Isao Ito
Nov 21, 2012·Nature Reviews. Neuroscience·Miguel L ConchaStephen W Wilson
Nov 20, 2016·The Journal of Physiological Sciences : JPS·Takuma KitanishiTakatoshi Hikida
Aug 14, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hiroshi Hamada
Jun 9, 2017·PloS One·Hikari UkaiIsao Ito

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