Right lung transplantation followed by left pneumonectomy in the rat

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
A T KawaguchiY Kawashima

Abstract

To develop a rodent lung transplant model which depends on graft function for survival, total microsutureless lung transplantation was carried out and followed by contralateral native pneumonectomy in the rat. Total non-microsuture right lung transplantation was undertaken using a cuff technique with anastomotic areas twice as big as those for the left lung transplantation. Inbred rats received either right (n = 10) or left lung isograft (n = 10) with non-microsuture techniques and underwent contralateral native pneumonectomy 2 weeks later to test the function of the grafted lung. While none of the left lung recipients could be disconnected from the respirator after right pneumonectomy, eight of ten right lung recipients tolerated left pneumonectomy, increased body weight and regained exercise capacity (oxygen uptake 49 +/- 4 ml/kg per min) comparable to that of control rats undergoing right hilar stripping and left pneumonectomy. The results suggest that the grafted right lung, but not the left lung, allows survival, growth and exercise of the recipient. Right lung transplantation followed by native left pneumonectomy may serve as a physiologic model of lung transplantation in the rat.

Citations

Mar 12, 2010·The Journal of Thoracic and Cardiovascular Surgery·Wenjun LiDaniel Kreisel
Aug 1, 2007·Archivos de bronconeumología·Norberto Santana RodríguezJorge Freixinet Gilart
Sep 29, 2009·International Journal of Pharmaceutics·Alan B WattsRobert O Williams
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Junichi KohmotoKenneth R McCurry
May 28, 2005·The Annals of Thoracic Surgery·Marc de PerrotShaf Keshavjee
Jan 30, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Wei ZhaiStephan Korom
Oct 15, 2019·Experimental Lung Research·Taufiek Konrad Rajab

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