Right Structural and Functional Reorganization in Four-Year-Old Children with Perinatal Arterial Ischemic Stroke Predict Language Production

ENeuro
Clément FrançoisAntoni Rodriguez-Fornells

Abstract

Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of four-year-old children with left perinatal arterial ischemic stroke (PAIS). Specifically, we gathered specific fine-grained developmental measures of receptive and productive aspects of language as well as standardized measures of cognitive development. We also collected structural neuroimaging data as well as functional activations during a passive listening story-telling fMRI task and a resting state session (rs-fMRI). Children with a left perinatal stroke showed larger lateralization indices of both structural and functional connectivity of the dorsal language pathway towards the right hemisphere that, in turn, were associated with better language outcomes. Importantly, the pattern of structural asymmetry was significantly more right-lateralized in children with a left perinatal brain insult than in a group of matched healthy controls. These results stron...Continue Reading

Citations

Nov 22, 2020·Brain and Language·Clément FrançoisAntoni Rodriguez-Fornells
May 16, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Christian NúñezAlfredo García-Alix
Jun 1, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Megan Ní BhroinArun L W Bokde

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Methods Mentioned

BETA
sedation
dissections

Software Mentioned

FMRIB Software Library
Diffusion Toolkit
Statistical Parameter Mapping
JASP
FMRIB Diffusion Toolbox ( FDT )
FNIRT
TORTOISE
FLIRT FMRIB Linear Image Registration Tool
house
Brain Extraction Tool

Related Concepts

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A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

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Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

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