Right-to-left shunts and hormonal therapy influence cerebral vasomotor reactivity in patients with migraine with aura

PloS One
Claudia AltamuraFabrizio Vernieri

Abstract

Patent Foramen Ovale and impaired cerebral hemodynamics were proposed among the pathophysiological mechanisms explaining the increased risk for stroke in patients with Migraine with Aura (MA). Our study aimed at comparing the vasomotor reactivity (VMR) of the anterior and the posterior cerebral circulation in patients with Migraine with Aura, in patients with acute vascular ischemic accidents, and in controls. We hypothesized that VMR in MA patients is preserved in the anterior circulation and reduced in the posterior circulation. We prospectively assessed with Transcranial Doppler the vasomotor reactivity to breath holding of the Middle and Posterior Cerebral Arteries (MCA, PCA) in MA patients, in acute vascular patients and healthy controls. We also evaluated the possible effect of clinical characteristics of MA (attack frequency, aura length or type, disease history), vascular factors and the presence of right-to-left shunt on VMR. Diverging from our hypothesis, MA patients displayed a higher breath-holding index (BHI) than controls in the MCA (1.84±0.47%/s vs 1.53±0.47%/s, p = .001) as well as in the PCA (1.87±0.65%/s vs 1.47±0.44%/s, p < .001). In MA patients, MCA BHI was higher in those with large right-to-left shunts (2....Continue Reading

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Citations

Jun 5, 2020·Neurological Research·Farid KhasiyevMehmet Akif Topcuoglu
Sep 2, 2020·Cephalalgia : an International Journal of Headache·Claudia AltamuraFabrizio Vernieri
Oct 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jemima Sa DzatorRachel Hx Wong
Feb 16, 2021·Frontiers in Neurology·Darja VisočnikMatija Zupan
Apr 6, 2021·Frontiers in Neurology·Claudia Altamura, Fabrizio Vernieri
May 8, 2021·Frontiers in Human Neuroscience·Claudia AltamuraGianluca Coppola
Jun 26, 2021·Journal of Neurology·Claudia AltamuraFabrizio Vernieri
Jul 27, 2021·Frontiers in Neurology·Jemima S A DzatorRachel H X Wong

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Methods Mentioned

BETA
PCA

Software Mentioned

SPSS

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