Right-to-left shunts as a cause of juxtacortical spots in patients with migraine

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G-J YoonK-H Cho

Abstract

Juxtacortical spots on fluid-attenuated inversion recovery (FLAIR) images can be frequently detected in patients with migraine. However, the origins of the cerebral lesions (including juxtacortical spots on FLAIR images) found in the previous studies are not known. We sought to investigate the association between juxtacortical spots on FLAIR images and right-to-left shunt (RLS) in migraine patients. Juxtacortical spots on FLAIR images were arbitrarily defined as small areas of hyperintensities in the juxtacortex and cortico-subcortical junction. The presence of RLS was examined by a transcranial Dopper (TCD) with the agitated saline test. The degree of RLS was categorized into four grades according to the number of microemboli: no shunt, <10 microbubbles (MB), >10 MB single spots pattern, and >10 MB shower/curtain pattern. We compared the results for migraine patients (n = 49) with those for healthy controls (n = 49). Juxtacortical spots on FLAIR images occurred in 38/98 subjects; of them, 27/49 (55.1%) had migraines and 11/49 (22.2%) were healthy controls (P = 0.002). The independent factors associated with juxtacortical spots on FLAIR images were female, migraine patients, and RLS by multivariate analysis. In migraine patient...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Apr 26, 2002·Cephalalgia : an International Journal of Headache·J G HeckmannB Neundörfer
Apr 1, 2003·Journal of Interventional Cardiology·Eva MorandiEustaquio Onorato
Jan 30, 2004·JAMA : the Journal of the American Medical Association·Mark C KruitLenore J Launer
May 6, 2004·JAMA : the Journal of the American Medical Association·Osama O Zaidat
Sep 15, 2004·Archives of Neurology·Richard H Swartz, Ralph Z Kern
Jul 12, 2005·Brain : a Journal of Neurology·Mark C KruitMark A van Buchem
Dec 24, 2005·Stroke; a Journal of Cerebral Circulation·Gian P AnzolaEustaquio Onorato
Apr 19, 2006·Headache·Peter Wilmshurst, Simon Nightingale
Jan 21, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gianfranco ButeraGiuseppe Sangiorgi
Feb 23, 2010·Lancet Neurology·Turgay DalkaraMichael A Moskowitz
Mar 13, 2010·Annals of Neurology·Ala NozariMichael A Moskowitz

❮ Previous
Next ❯

Citations

Aug 1, 2014·Clinical Neurology and Neurosurgery·Kyung Wook KangKang-Ho Choi
Jan 18, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Jun 11, 2016·Journal of Stroke·Mi Ji LeeChin-Sang Chung
Mar 12, 2017·Current Neurology and Neuroscience Reports·Melissa Rayhill, Rebecca Burch
Apr 30, 2020·ACS Chemical Neuroscience·Swapnil RautPallab Bhattacharya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.