PMID: 8607683Apr 1, 1996Paper

Right ventricular blood flow during left ventricular support in an experimental porcine model

The Annals of Thoracic Surgery
P J HendryK Rajagopalan

Abstract

Right ventricular blood flow may be adversely affected during left ventricular assist device (LVAD) use leading to right ventricular (RV) ischemia and RV dysfunction. This study characterized normal RV blood flow responses to LVAD operation. Seven Yorkshire pigs weighing 74.4 +/- 3.4 kg underwent right coronary artery blood flow measurements with an ultrasonic flow probe and injection of radiolabeled microspheres. A Thoratec LVAD was used in either synchronous or asynchronous modes and RV loading was increased using a pulmonary artery snare. The RV blood flow was compared between three regions that differed in proximity to the right coronary artery: proximal segment, mid-RV, and distal. The right ventricular distal flow was 0.93 +/- 0.07 mL x min-1 x g-1 compared with 0.74 +/- 0.06 mL x min-1 x g-1 at right ventricular proximal flow during control measurements (p = 0.0001). This difference was maintained during LVAD operation in either synchronous or asynchronous modes and also during pulmonary artery constriction. Global RV flow is not adversely affected by LVAD use. A flow gradient occurs along the right coronary artery with the distal vascular bed having relatively less reserve, which may be more susceptible to ischemia in p...Continue Reading

References

Jul 11, 1988·The American Journal of Cardiology·C Oakley
Feb 1, 1985·World Journal of Surgery·D J FarrarJ D Hill
Oct 1, 1971·The Journal of Clinical Investigation·H BrooksE H Sonnenblick
Jan 1, 1993·The Annals of Thoracic Surgery·D J Farrar, J D Hill

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Citations

Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Steve XydasSimon Maybaum
Jul 2, 2009·Artificial Organs·Diyar Saeed, Kiyotaka Fukamachi
Jan 1, 1997·Journal of Cardiac Surgery·C KreutzerG Kreutzer
Mar 5, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kazuhiro EyaKamuran Kadipasaoglu

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