Right Ventricular Dysfunction and Its Contribution to Morbidity and Mortality in Left Ventricular Heart Failure

Current Heart Failure Reports
Amresh Raina, Talha Meeran

Abstract

In patients with left-sided HF, there has been less emphasis on the pathophysiology of the RV in terms of diagnostic evaluation and treatment, versus focus on structural abnormalities of the LV. This review seeks to delineate the importance of RV dysfunction in terms of its contribution to symptomatic limitations and cardiovascular outcomes in patients with left-sided HF. Recent studies have demonstrated that RV dysfunction is common in both HFpEF and HFrEF, but more pronounced in HFrEF. LV dysfunction and atrial fibrillation are most commonly associated with RV dysfunction in left-sided HF. RV dysfunction may develop due to afterload-dependent and afterload-independent pathways. Regardless, RV dysfunction is strongly associated with functional limitations and worsened survival in patients with left-sided HF. In patients with HFpEF, a recent study showed that RV failure was the most common cause of overall mortality. Among LVAD patients and patients post-cardiac transplantation, RV dysfunction is also strongly associated with survival. Despite a number of previous and ongoing clinical trials that target the RV directly or decrease RV afterload in left-sided HF, there are no definitive therapies specifically targeting RV dysfunc...Continue Reading

References

Aug 1, 1971·American Journal of Surgery·R B GrieppN E Shumway
Apr 1, 1995·Journal of the American College of Cardiology·T G Di SalvoG W Dec
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M CarrierL C Pelletier
Oct 5, 2001·Journal of the American College of Cardiology·B Stobierska-DzierzekR E Michler
May 3, 2002·Journal of the American College of Cardiology·Leonardo A M ZornoffUNKNOWN SAVE Investigators
May 14, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jaroslav MeluzinLadislav Dusek
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patricia P ChangEdward K Kasper
Apr 28, 2007·European Journal of Heart Failure·Jesper KjaergaardChristian Hassager
Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sarinya PuwanantJuan M Aranda
Dec 9, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J Raymond FitzpatrickY Joseph Woo
Mar 28, 2009·Journal of the American College of Cardiology·Carolyn S P LamMargaret M Redfield
Oct 20, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Einar GudeArne K Andreassen
Oct 21, 2009·The American Journal of Cardiology·Omar A MinaiJames K Stoller
Feb 6, 2010·The Journal of Thoracic and Cardiovascular Surgery·Robert L KormosUNKNOWN HeartMate II Clinical Investigators
Mar 30, 2010·The American Journal of Cardiology·Stavros G DrakosPatrick W Fisher
Jan 10, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richa AgarwalMardi Gomberg-Maitland
May 9, 2012·American Journal of Respiratory and Critical Care Medicine·Mario KasnerCarsten Tschöpe
Jan 23, 2013·Current Opinion in Cardiology·Bhagat PatlollaFrancois Haddad
Mar 13, 2013·JAMA : the Journal of the American Medical Association·Margaret M RedfieldUNKNOWN RELAX Trial
Jun 19, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Amresh RainaPaul R Forfia
Jul 9, 2013·Journal of the American College of Cardiology·Janne Mykland HildeKjetil Steine
Jul 17, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rey P VivoJerry D Estep
Aug 13, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Koji TakedaHiroo Takayama
Apr 29, 2014·Journal of the American College of Cardiology·Seok-Jae HwangBarry A Borlaug
May 31, 2014·European Heart Journal·Vojtech MelenovskyBarry A Borlaug
May 4, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Koji TakedaYoshifumi Naka
May 16, 2015·Journal of Cardiothoracic and Vascular Anesthesia·André Y DenaultJean Lambert
Jul 15, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chris J KapeliosJohn N Nanas

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Citations

Jan 12, 2020·Heart Failure Reviews·Anna S MuellerJonathan N Ginns
Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Szu-Ying TsaiShan-Hui Huang
Jul 3, 2020·Animal Models and Experimental Medicine·Michael Nguyen-TruongZhijie Wang
Jan 13, 2021·Annals of Clinical Biochemistry·Melissa HarbrückerMichael Behnes
Mar 24, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Catherine G IrelandSteven Hsu
Nov 27, 2021·Heart Failure Reviews·Pamelika DasSomasundaram Arumugam

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