Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy

Journal of Oncology
Anna CallejaPaaladinesh Thavendiranathan

Abstract

Background. Right ventricular (RV) dysfunction during cancer therapy related cardiotoxicity and its prognostic implications have not been examined. Aim. We sought to determine the incidence and prognostic value of RV dysfunction at time of LV defined cardiotoxicity. Methods. We retrospectively identified 30 HER2+ female patients with breast cancer treated with trastuzumab (± anthracycline) who developed cardiotoxicity and had a diagnostic quality transthoracic echocardiography. LV ejection fraction (LVEF), RV fractional area change (RV FAC), and peak systolic longitudinal strain (for both LV and RV) were measured on echocardiograms at the time of cardiotoxicity and during follow-up. Thirty age balanced precancer therapy and HER2+ breast cancer patients were used as controls. Results. In the 30 patients with cardiotoxicity (mean ± SD age 54 ± 12 years) RV FAC was significantly lower (42 ± 7 versus 47 ± 6%, P = 0.01) compared to controls. RV dysfunction defined by global longitudinal strain (GLS < -20.3%) was seen in 40% (n = 12). During follow-up in 16 out of 30 patients (23 ± 15 months), there was persistent LV dysfunction (EF < 55%) in 69% (n = 11). Concomitant RV dysfunction at the time of LV cardiotoxicity was associated wit...Continue Reading

References

Jul 1, 1991·Clinical Nuclear Medicine·E C BarendswaardE K Pauwels
Apr 13, 2000·The New England Journal of Medicine·G M FelkerE K Kasper
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew SeidmanDeborah Keefe
Jul 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Javier GanameLuc Mertens
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Feb 2, 2010·Journal of the American College of Cardiology·Daniela CardinaleCarlo M Cipolla
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniela CardinaleCarlo M Cipolla
Feb 23, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Victor Mor-AviJosé Luis Zamorano
Jul 23, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Christina ChrysohoouChristodoulos Stefanadis
Sep 2, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Asli TanindiMustafa Benekli
Oct 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Soulef GuendouzThibaud Damy
Aug 18, 2012·Asia-Pacific Journal of Clinical Oncology·Begül Yağci-KüpeliMünevver Büyükpamukçu
Nov 20, 2012·Journal of the American College of Cardiology·Jersey ChenCary P Gross
Dec 12, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Teerapat YingchoncharoenThomas H Marwick
May 20, 2014·The American Journal of Cardiology·Guilherme H OliveiraW H Wilson Tang
Aug 31, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Juan Carlos PlanaPatrizio Lancellotti
Sep 23, 2014·JACC. Cardiovascular Imaging·Mao-Yuan M SuWen-Yih I Tseng

❮ Previous
Next ❯

Citations

Feb 14, 2017·Clinical Cardiology·Marijana TadicOleksandr Danylenko
Jul 7, 2017·Expert Opinion on Drug Metabolism & Toxicology·Neha BansalSteven E Lipshultz
Feb 20, 2018·Expert Review of Cardiovascular Therapy·Lucia VenneriRajdeep S Khattar
Feb 28, 2019·European Journal of Heart Failure·Kalliopi KeramidaPetros Nihoyannopoulos
Feb 29, 2016·Current Treatment Options in Cardiovascular Medicine·Aarti A Patel, Arthur J Labovitz
Sep 29, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alicia M MaceiraJose Salazar
Jan 7, 2021·Heart Failure Reviews·Diana GonciarLucia Agoston-Coldea
Oct 17, 2020·Clinical Science·Chandu SadasivanGavin Y Oudit
Aug 28, 2021·Medicina·Liliana Maria RadulescuAnca Dana Buzoianu
Sep 21, 2021·Frontiers in Cardiovascular Medicine·Christopher YuKazuaki Negishi
Nov 17, 2021·The International Journal of Cardiovascular Imaging·Géris MazzuttiAngela Barreto Santiago Santos

❮ Previous
Next ❯

Software Mentioned

MedCalc
VVI
Vector Velocity Imaging ( VVI )
MUGA

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.