Right ventricular function after brain death: response to an increased afterload

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
G SzabóS Hagl

Abstract

A major cause of early postoperative morbidity and mortality after cardiac transplantation is right ventricular (RV) failure which is attributed to the inability of the donor's RV to acutely compensate for the recipient's elevated pulmonary vascular resistance. This study was performed to determine: (1) the acute effects of brain death on the RV function; and (2) the adaptation potential of the RV to a progressive increase in RV afterload. In 13 anesthetized, open-chest dogs (eight with brain death vs. five control with sham operation), brain death was induced by inflation of a subdural balloon catheter. Heart rate, RV systolic and end-diastolic pressure (RVSP, RVEDP), pulmonary arterial pressure (PAP), and cardiac output (CO), and pressure-length loops (sonomicrometry) were recorded. Afterload increase was induced 2 h after brain death induction by constriction of the pulmonary artery with an increase in RVP from 25 to 50 mmHg in 5 mmHg steps. Cushing phenomenon occurred within a few minutes after brain death induction, with a significant increase of HR (229 +/- 10 vs. 89 +/- 6 min(-1), P < 0.001), CO (3.2 +/- 0.2 vs. 1.7 +/- 0.1 l/min, P < 0.001), PAP (30.4 +/- 2.5 vs. 15.5 +/- 1.3 mmHg, P < 0.01) RVSP (55 +/- 5 vs. 23 +/- 2 ...Continue Reading

References

Mar 1, 1979·Circulation Research·W L MaughanM L Weisfeldt
Nov 1, 1976·The American Journal of Physiology·R A RainesJ W Covell
Jul 1, 1970·The Journal of Clinical Investigation·R E Brashear, J C Ross
Jun 1, 1974·The American Journal of Cardiology·E W StoolJ H Mitchell
May 1, 1983·Critical Care Medicine·W J Sibbald, A A Driedger
Dec 1, 1993·Cardiovascular Research·M Irlbeck, H G Zimmer
Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C SebeningS Hagl
May 1, 1996·The Annals of Thoracic Surgery·A C NicolosiD C Warltier

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Citations

Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gábor SzabóAlexander Juhász-Nagy
May 16, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M J WilhelmN L Tilney
Apr 4, 2014·Critical Care : the Official Journal of the Critical Care Forum·Joerg KrebsThomas Luecke
Jul 16, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marius BermanStephen Large
Jun 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·Serban C StoicaStephen R Large
Aug 25, 2006·The Annals of Thoracic Surgery·Gábor SzabóSiegfried Hagl
Jul 4, 2001·The Journal of Thoracic and Cardiovascular Surgery·M H DantonL Aklog
May 21, 2013·Jornal de pediatria·Joaquim E B Cabral, Jaques Belik
Jul 27, 2010·Journal of Neuroscience Methods·G PomperB K Podesser
May 2, 2007·Current Cardiology Reports·Mobusher Mahmud, Hunter C Champion
Aug 18, 2009·Acta Anaesthesiologica Scandinavica·J F Bugge
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M De VroomenJ Baan
Jun 14, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Tom VerbelenBart Meyns
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M de VroomenJ Baan
Jun 28, 2021·Clinical Transplantation·Hoong Sern LimJorge Mascaro

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