Right ventricular function mirrors clinical improvement with use of prostacyclin analogues in pediatric pulmonary hypertension

Pulmonary Circulation
Rachel K HopperLaura Mercer-Rosa

Abstract

Pulmonary hypertension (PH) causes significant morbidity and mortality in children due to right ventricular (RV) failure. We sought to determine the effect of prostacyclin analogues on RV function assessed by echocardiography in children with PH. We conducted a retrospective cohort study of children with PH treated with a prostacyclin analogue (epoprostenol or treprostinil) between January 2001 and August 2015 at our center. Data were collected before initiation of treatment (baseline) and at 1-3 and 6-12 months after. Protocolized echocardiogram measurements including tricuspid annular plane systolic excursion (TAPSE) and RV global longitudinal strain were made with blinding to clinical information. Forty-nine individuals (65% female), aged 0-29 years at the time of prostacyclin initiation were included. Disease types included pulmonary arterial hypertension (idiopathic [35%], heritable [2%], and congenital heart disease-associated [18%]), developmental lung disease (43%), and chronic thromboembolic PH (2%). Participants received intravenous (IV) epoprostenol (14%) and IV/subcutaneous (SQ) (67%) or inhaled (18%) treprostinil. Over the study period, prostacyclin analogues were associated with improvement in TAPSE ( P = 0.007), ...Continue Reading

References

Mar 9, 1999·Circulation·R J BarstA P Fishman
Aug 2, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Fadi JamalMichel Ovize
Aug 5, 2006·American Journal of Respiratory and Critical Care Medicine·Paul R ForfiaPaul M Hassoun
Dec 25, 2007·Journal of the American College of Cardiology·Lori B Daniels, Alan S Maisel
Jul 5, 2008·International Journal of Cardiology·Astrid E LammersSheila G Haworth
May 3, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Raymond L BenzaIrene M Lang
Oct 30, 2012·The American Journal of Cardiology·Evan L HardegreeGarvan C Kane
Aug 10, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Laura Mercer-RosaSteven M Kawut
Dec 21, 2013·Journal of the American College of Cardiology·D Dunbar IvyMaurice Beghetti
Dec 21, 2013·Journal of the American College of Cardiology·Gerald SimonneauRogiero Souza
Mar 4, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Philip T LevyGautam K Singh
Mar 25, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sudarshan RajagopalZainab Samad
Apr 1, 2014·Journal of the American College of Cardiology·Willemijn M H ZijlstraRolf M F Berger
Jul 19, 2014·The European Respiratory Journal·Mark-Jan PloegstraRolf M F Berger
Sep 28, 2014·The European Respiratory Journal·Jose Gomez-ArroyoNorbert F Voelkel
Oct 13, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kenichi OkumuraMark K Friedberg
Mar 11, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Philip T LevyGautam K Singh
Aug 25, 2015·European Journal of Pediatrics·Chantal A Ten KateUlrike S Kraemer
Aug 25, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Michael V Di MariaKendall S Hunter
Sep 12, 2015·Journal of the American College of Cardiology·Jacqueline Kreutzer
Feb 27, 2016·Journal of the American College of Cardiology·Maurice BeghettiTilman Humpl
Mar 21, 2016·The Lancet. Respiratory Medicine·Mark-Jan PloegstraRolf M F Berger
Jul 15, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·H SunW Rodriguez
Sep 20, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Philip T LevyGautam K Singh

❮ Previous
Next ❯

Citations

Mar 14, 2020·Journal of Cardiovascular Pharmacology·Arthur GavottoPascal Amedro
Sep 23, 2019·Pediatric Cardiology·Kiona Y AllenShobha S Natarajan
Aug 14, 2019·Heart Failure Reviews·Michail PapamichalisFilippos Triposkiadis
Jan 22, 2020·Paediatric Drugs·Catherine M AvitabileDavid Dunbar Ivy
Jul 31, 2020·Annals of the American Thoracic Society·Catherine M AvitabileLaura Mercer-Rosa
Dec 10, 2020·Arquivos brasileiros de cardiologia·Samira Saady MorhyMarcelo Luiz Campos Vieira

❮ Previous
Next ❯

Software Mentioned

TomTec
Syngo
STATA

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
M B IzzatG D Angelini
© 2022 Meta ULC. All rights reserved