PMID: 3215193Dec 1, 1988Paper

Right ventricular performance and pulmonary haemodynamics in adolescent and adult patients with cystic fibrosis

European Journal of Pediatrics
O C BurghuberM Götz

Abstract

A combined haemodynamic and radionuclide approach was used to evaluate right ventricular performance in 16 adolescent and adult patients with cystic fibrosis (CF). There were nine patients with mild arterial hypoxaemia (PaO2 greater than 80% of predicted) and normal resting pulmonary artery pressure and seven patients with severe arterial hypoxaemia (PaO2 less than 70% of predicted) and resting pulmonary arterial hypertension (PH). The right ventricular ejection fraction (RVEF) by equilibrium angiocardiography using krypton 81m as a tracer and stroke volume index (SVI) by thermodilution techniques were measured simultaneously and right ventricular end-diastolic and end-systolic volumes were derived. RVEF was normal in CF patients without PH (58.9 +/- 7.2%) but was reduced in those with PH (45.4 +/- 2.6%). There was a statistically significant inverse linear correlation between RVEF and afterload as assessed by mean pulmonary artery pressure (Pap: r = -0.76) and pulmonary vascular resistance (PVR: r = -0.78), indicating that RVEF ist afterload-dependent. Right ventricular function, however, as assessed by right ventricular end-systolic pressure-volume relations was even higher in CF patients with PH, indicating preserved or even...Continue Reading

References

Sep 1, 1979·The Journal of Pediatrics·B E ChippsB J Rosenstein
Mar 1, 1979·Circulation Research·W L MaughanM L Weisfeldt
Jan 1, 1987·Respiration; International Review of Thoracic Diseases·O C Burghuber
May 1, 1983·Critical Care Medicine·W J Sibbald, A A Driedger
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·O BurghuberR Höfer
Dec 1, 1980·European Journal of Nuclear Medicine·W H KnappH H Vollhaber
Jul 1, 1958·A.M.A. Journal of Diseases of Children·H SHWACHMAN, L L KULCZYCKI
Oct 1, 1964·The Journal of Pediatrics·R M GOLDRINGD H ANDERSEN
Jul 1, 1952·American Heart Journal·C E TOMLINJ W HURST

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Citations

Sep 21, 2013·Current Opinion in Pulmonary Medicine·Adriano R Tonelli
May 15, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adriano R TonelliMaher A Baz

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