Right ventricular pressure elevated in one-kidney, one clip Goldblatt hypertensive rats

Clinical and Experimental Hypertension : CHE
Farzaneh KetabchiElaheh Mashghoolozekr

Abstract

Both renal and respiratory diseases are common with high mortality rate around the world. This study was the first to compare effects of two kidneys, one clip (2K1C) and one-kidney, one clip (1K1C) Goldblatt hypertension on right ventricular pressure during normal condition and mechanical ventilation with hypoxia gas. Male Sprague-Dawley rats were subjected to control, 2K1C, or 1K1C groups. Twenty-eight days after the first surgery, animals were anesthetized, and femoral artery and vein, and right ventricle cannulated. Systemic arterial pressure and right ventricular systolic pressures (RVSP) were recorded during ventilation the animals with normoxic or hypoxic gas. RVSP in the 1K1C group was significantly more than the control and 2K1C groups during baseline conditions and ventilation the animals with hypoxic gas. Administration of antioxidant Trolox increased RVSP in the 1K1C and control groups compared with their baselines. Furthermore, there was no alteration in RVSP during hypoxia in the presence of Trolox. This study indicated that RVSP only increased after 28 days induction of 1K1C but not 2K1C model. In addition, it seems that the response to hypoxic gas and antioxidants in 1K1C is more than 2K1C. These data also sugges...Continue Reading

References

Sep 1, 1983·Hypertension·U Ackermann, S R Tatemichi
Mar 7, 2001·Hypertension·L O LermanJ C Romero
Jul 20, 2002·Respiratory Physiology & Neurobiology·Richard M LeachJeremy P T Ward
Aug 10, 2002·Journal of Vascular Surgery·Javid SadjadiJ Gregory Modrall
May 13, 2003·Chest·Mordechai YiglaShimon A Reisner
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·William J WelchChristopher S Wilcox
Apr 23, 2008·Hypertension·Minolfa C Prieto-CarrasqueroL Gabriel Navar
Jul 19, 2008·American Journal of Nephrology·Saeed Abdelwhab, Samah Elshinnawy
Feb 28, 2009·American Journal of Respiratory and Critical Care Medicine·Anderson J FerreiraMohan K Raizada
Apr 3, 2010·Journal of the American Society of Nephrology : JASN·Ming LuJin-Song Bian
Dec 16, 2010·Current Opinion in Anaesthesiology·A Mark EvansAmira Mahmoud
Jan 5, 2011·Nephron. Clinical Practice·Luca Di LulloPasquale Polito
Apr 5, 2012·European Journal of Histochemistry : EJH·I Kasacka, E Arciszewska
Jul 28, 2012·Pulmonary Circulation·Harm J BogaardNorbert F Voelkel
Jun 7, 2013·Kidney International·Meghan E SiseRichard N Channick
Nov 4, 2016·Renal Failure·Zynab KarimiSeyed Mostafa S Moosavi

❮ Previous
Next ❯

Citations

Mar 7, 2019·Journal of Cardiovascular Pharmacology·Maryam KhoramzadehFarzaneh Ketabchi
Dec 17, 2020·Kidney & Blood Pressure Research·Pei-Li ChouChiang-Ting Chien

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved