Right ventricular remodeling in restrictive ventricular septal defect.

Journal of Molecular and Cellular Cardiology
Gretel MonrealMark A Gerhardt

Abstract

Restrictive ventricular septal defect (rVSD) presents with little/no hemodynamic aberrations despite a patent septal defect. Clinically, these patients are observed with the hope that the defect will functionally close over time without the need for surgical repair and development of heart failure. Without evidence supporting a definitive therapeutic strategy, rVSD patients may have increased risk of a poor outcome. We tested the hypothesis that rVSD results in subclinical RV diastolic dysfunction and molecular remodeling. Five pigs underwent surgical rVSD creation. Echocardiography, hemodynamics, myocyte contractility experiments, and proteomics/Western blot were performed 6-weeks post-rVSD and in controls. *p<0.05. LV and RV hemodynamics in rVSD were comparable to controls. The tricuspid valve early/late diastolic inflow velocity ratio (TV E/A ratio) decreased from 1.6+/-0.05 in controls to 1.0+/-0.08* in rVSD, indicating RV diastolic dysfunction. rVSD RV myocytes showed abnormalities in contraction (departure velocity (Vd) -51%*, Vd time +55%*) and relaxation (return velocity (Vr) -50%*, Vr time +62%*). Mitochondrial proteins (fatty acid, TCA cycle) increased 2-fold*, indicating heightened RV work. Desmin protein upregulated...Continue Reading

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Citations

Jan 1, 2016·Fetal and Pediatric Pathology·Gloria PelizzoValeria Calcaterra
Apr 19, 2011·Journal of Anatomy·Masahito YamamotoYoshinobu Ide
Aug 6, 2014·Proteomics. Clinical Applications·Anna BassolsJoan Tibau
Aug 31, 2018·Cardiology in the Young·Marie MaagaardVibeke E Hjortdal

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