PMID: 2865518Nov 9, 1985Paper

RII and RIII type resistance of Plasmodium falciparum to combination of mefloquine and sulfadoxine/pyrimethamine in Indonesia

Lancet
S L HoffmanP Heizmann

Abstract

2 of 36 Plasmodium falciparum infections were resistant (RII and RIII) in vivo to the combination of mefloquine (M) and sulfadoxine-pyrimethamine (SP) in Jayapura, Irian Jaya, Indonesia. Expected absorption of mefloquine and pyrimethamine was confirmed in the one resistant patient from whom sera were available, and the isolate from this patient was sensitive to mefloquine in vitro. Only 2 of 41 infections studied at the same time were resistant in vivo to SP. There was no clinical advantage of MSP compared with SP, and limited observations suggest there may be a disadvantage.

Citations

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L HoffmanH Marwoto
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·E C ReisingerM Dietrich
Feb 27, 1988·Lancet
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·D J KrogstadP H Schlesinger
Sep 23, 1989·BMJ : British Medical Journal·J M BestE Miller
Aug 27, 2002·Annals of Tropical Medicine and Parasitology·D J FryauffJ K Baird
Sep 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MaynadiéL Yarzabal
Feb 1, 1989·Journal of Chemotherapy·L Donno

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