Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study)

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Kazunari TominagaTetsuo Arakawa

Abstract

Functional dyspepsia (FD), a heterogeneous disorder, involves multiple pathogenetic mechanisms. Developing treatments for FD has been challenging. We performed a randomized, placebo-controlled, double-blind clinical trial to determine the efficacy of rikkunshito, a Japanese herbal medicine, in FD patients. FD patients (n = 192) who met the Rome III criteria without Helicobacter pylori infection, predominant heartburn, and depression were enrolled at 56 hospitals in Japan. After 2 weeks of single-blind placebo treatment, 128 patients with continuous symptoms were randomly assigned to 8 weeks of rikkunshito (n = 64) or placebo (n = 61). The primary efficacy endpoint was global assessment of overall treatment efficacy (OTE). The secondary efficacy endpoints were improvements in upper gastrointestinal symptoms evaluated by the Patient Assessment of Upper Gastrointestinal Disorders-Symptom Severity Index (PAGI-SYM), the Global Overall Symptom scale (GOS), and the modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (m-FSSG), and psychological symptoms evaluated by the Hospital Anxiety and Depression Scale (HADS). Rikkunshito increased OTE compared to placebo at 8 weeks (P = .019). Rikkunshito improved upper g...Continue Reading

References

Nov 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·O A Abiodun
Sep 9, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dennis A RevickiDominique Dubois
Jan 18, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A M RentzD A Revicki
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P Enck, S Klosterhalfen
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Yuhki SatoMasaharu Takeyama
Jan 31, 2006·Alimentary Pharmacology & Therapeutics·S J O Veldhuyzen van ZantenK Nevin
May 9, 2006·Gastroenterology·Jan TackVincenzo Stanghellini
Aug 12, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S KindtJ Tack
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiko Kito, Hikaru Suzuki
Apr 1, 2010·Alimentary Pharmacology & Therapeutics·F CremoniniA J Lembo
Dec 24, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ShiratoriS Fukudo
Nov 15, 2011·Journal of Gastroenterology·Kazunari TominagaUNKNOWN GERD 4 Study Group
Jan 9, 2013·Nature Reviews. Gastroenterology & Hepatology·Eamonn M M Quigley, Brian E Lacy
Aug 21, 2013·Alimentary Pharmacology & Therapeutics·R IwakiriT Arakawa
Apr 2, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M NahataH Takeda
Apr 16, 2014·Digestive Diseases·F Carbone, J Tack
Apr 29, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H SuzukiUNKNOWN Rikkunshito study group
Jan 15, 2015·Journal of Gastroenterology·Hiroto MiwaUNKNOWN Japanese Society of Gastroenterology
May 13, 2015·The American Journal of Gastroenterology·Maria Ines Pinto-SanchezPremysl Bercik
Jul 19, 2015·Gut·Kentaro SuganoUNKNOWN faculty members of Kyoto Global Consensus Conference
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·J TackL Van Oudenhove
Feb 3, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H MiwaJ Watari
May 6, 2016·Gastroenterology·Vincenzo StanghelliniNicholas J Talley

❮ Previous
Next ❯

Citations

Sep 11, 2018·Current Opinion in Gastroenterology·Jan TackFlorencia Carbone
Apr 11, 2019·The Journal of Pharmacology and Experimental Therapeutics·Yumi HaradaHiroyuki Kobayashi
Oct 1, 2019·Expert Opinion on Investigational Drugs·Jan TackFlorencia Carbone
Jan 5, 2020·Expert Opinion on Pharmacotherapy·A VandenbergheJ Tack
Oct 15, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Imke MasuyJan Tack
Oct 16, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yasushi FunakiKunio Kasugai
Nov 2, 2019·Journal of Gastroenterology and Hepatology·Niandi TanYinglian Xiao
Aug 9, 2020·Journal of Gastroenterology and Hepatology·Seok-Jae KoJae-Woo Park
Sep 6, 2018·The American Journal of Gastroenterology·Tadayuki Oshima, Hiroto Miwa
Mar 30, 2019·Alimentary Pharmacology & Therapeutics·Imke MasuyJan Tack
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Karen Van Den HouteJan Tack
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenyu WuChunyang Zhu
May 30, 2020·Journal of Paediatrics and Child Health·Scott Nightingale, Ajay Sharma
Aug 9, 2020·Frontiers in Nutrition·Shin TakayamaTadashi Ishii
Dec 2, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Kok-Ann GweeXu-Dong Tang
Nov 13, 2020·World Journal of Gastroenterology : WJG·Jian-Hong DingJing-Yu Xu
Apr 5, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian E LacyMaria Vazquez-Roque
Jul 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jin-Yong JoungChang-Gue Son
Aug 18, 2021·The American Journal of Gastroenterology·Xinyi HuangHiroto Miwa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.