Rilpivirine.

Drugs
Mark Sanford

Abstract

Rilpivirine is an orally administered, non-nucleoside reverse transcriptase inhibitor that is a component drug in combination therapy for antiretroviral-naive patients with HIV-1 infection. The randomized, double-blind, double-dummy, multinational ECHO and THRIVE trials in antiretroviral-naive adult patients with HIV-1 infection compared rilpivirine with efavirenz, administered with background nucleoside/nucleotide antiretroviral regimens. Rilpivirine 25 mg once daily recipients had a treatment response (confirmed plasma HIV-1 RNA level of <50 copies/mL at 48 weeks; primary endpoint) that was noninferior to that of efavirenz 600 mg once daily recipients. The response rates in the rilpivirine and efavirenz groups were 83% and 84% (ECHO) and 87% and 83% (THRIVE). Virological failure rates in rilpivirine and efavirenz groups in the intent-to-treat analysis were 11% and 4% in the ECHO trial and 7% and 5% in the THRIVE trial. In a pooled analysis of both trials, in rilpivirine recipients with an HIV-1 RNA level of >100,000 copies/mL at baseline, the virological failure rate at 48 weeks was 15% (vs 6% with efavirenz), whereas in those with a level of ≤100,000 copies/mL, the virological failure rate was 4% (vs 3% with efavirenz). In g...Continue Reading

References

Oct 4, 2003·Nature Reviews. Drug Discovery·William LewisWilliam C Copeland
Oct 2, 2008·HIV Medicine·B G GazzardUNKNOWN BHIVA Treatment Guidelines Writing Group
Nov 1, 2008·Drugs·Emma D Deeks, Gillian M Keating
Dec 10, 2009·The Annals of Pharmacotherapy·Jessica AdamsChristopher D Miller
Feb 18, 2010·Antimicrobial Agents and Chemotherapy·Gerben van 't KloosterLieven Baert
Jul 20, 2010·JAMA : the Journal of the American Medical Association·Melanie A ThompsonUNKNOWN International AIDS Society-USA

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Citations

Aug 28, 2012·Clinical Drug Investigation·Katherine A Lyseng-Williamson, Lesley J Scott
Feb 3, 2015·Enfermedades infecciosas y microbiología clínica·Diego M CecchiniMaría B Bouzas
Jul 9, 2013·The Journal of Antimicrobial Chemotherapy·D B FofanaS Lambert-Niclot
May 4, 2016·The Journal of Antimicrobial Chemotherapy·Nicolas HohmannWalter E Haefeli
Nov 6, 2018·Expert Review of Anti-infective Therapy·Martina ProperziEugenia Quiros-Roldan

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