PMID: 9002062Dec 1, 1996Paper

Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat

Journal of Neurotrauma
T K McIntoshJ M Stutzmann

Abstract

Several potential mechanisms are involved in mediating the pathophysiology of traumatic brain injury (TBI), including inflammatory processes and excitotoxicity. In the present study, we evaluated the ability of the use-dependent sodium channel inhibitor Riluzole to attenuate cognitive and neurologic motor deficits and reduce regional cerebral edema and histologic cell damage following lateral fluid-percussion (FP) brain injury in rats (n = 109). In study 1, 58 anesthetized male Sprague-Dawley rats (350-400 g) were subjected to FP brain injury of moderate severity (2.3-2.5 atm). Fifteen minutes following brain injury, animals randomly received an i.v. bolus of either Riluzole (4 mg/kg, n = 11), Riluzole (8 mg/kg, n = 11), or glycol vehicle (n = 20), followed by 6 h and 24 h s.c. injections (identical dose). Surgically prepared but uninjured animals received vehicle (n = 16) and served as controls. Animals were evaluated for cognitive deficits at 48 h postinjury and killed for assessment of regional brain edema. Administration of vehicle or Riluzole (4 mg/kg x 3) had no significant effect on memory or edema, whereas Riluzole (8 mg/kg x 3) significantly attenuated post-traumatic cognitive dysfunction (p < 0.05). In study 2, a seco...Continue Reading

References

Jan 13, 1978·Brain Research·D S OltonF H Gage
Dec 1, 1991·Pflügers Archiv : European journal of physiology·E Benoit, D Escande
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G L CliftonR L Hayes
Apr 30, 1990·Brain Research·D CorbettR A Jonas
Jan 1, 1990·Journal of Neurotrauma·Y ShapiraE Shohami
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonU Ungerstedt
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D T Monaghan, C W Cotman
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Dec 1, 1984·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·A J Parkin
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Mar 13, 1995·Brain Research·A E JohnsonH E Albers
Mar 24, 1995·European Journal of Pharmacology·F AlaouiJ M Stutzmann
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S H GrahamR P Simon
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M J LeachM Nobbs
Dec 31, 1993·Behavioural Brain Research·R J HammB R Pike
Mar 3, 1994·The New England Journal of Medicine·G BensimonV Meininger

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Citations

Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·P M Lea, A I Faden
Nov 25, 2000·Journal of the Neurological Sciences·O Hurko, F S Walsh
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Aug 14, 2008·CNS Drugs·Christopher PittengerGerard Sanacora
Sep 14, 2007·Acta Oto-laryngologica·Heloisa Juliana Zabeu Rossi CostaPaulo Roberto Lazarini
Dec 5, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Shuan-Cheng RenZhi-Ru Zhu
Feb 11, 2000·Annals of the New York Academy of Sciences·W S Carbonell, M S Grady
May 25, 2011·Pharmacology & Therapeutics·Alexander G RabchevskyJoe E Springer
Dec 17, 2008·Annals of the New York Academy of Sciences·Mark P Mattson
Oct 16, 2015·Reviews in the Neurosciences·Mrinmay ChakrabartiSwapan K Ray
Jun 23, 2015·Journal of Neurochemistry·Andréia C K Fontana
May 6, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·T LescotL Puybasset
Apr 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·L Lang-LazdunskiM Lazdunski
Aug 14, 1999·Journal of Neurotrauma·S N KroppenstedtA W Unterberg
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J A CheneyT K McIntosh
Nov 21, 2017·Translational Stroke Research·Mohammad KhaksariNader Shahrokhi
Dec 31, 1997·Journal of Neurotrauma·T P Obrenovitch, J Urenjak

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