Riluzole in psychiatry: a systematic review of the literature.

Expert Opinion on Drug Metabolism & Toxicology
Carlos A Zarate, Husseini K Manji

Abstract

The glutamate system seems to be an important contributor to the pathophysiology of mood and anxiety disorders. Thus, glutamatergic modulators are reasonable candidate drugs to test in patients with mood and anxiety disorders. Riluzole, a neuroprotective agent with anticonvulsant properties approved for the treatment of amyotrophic lateral sclerosis (ALS) is one such agent. To assess the potential risks and benefits of riluzole treatment in psychiatric patients. A PubMed search was performed using the keywords 'riluzole', 'inhibitor of glutamate release' and 'glutamatergic modulator' to identify all clinical studies and case reports involving riluzole in psychiatric patients. Riluzole's side effect profile is favorable and preliminary results regarding riluzole for the treatment of severe mood, anxiety and impulsive disorders are encouraging.

References

Jan 1, 1989·Psychopharmacology·J M StutzmannJ C Blanchard
Mar 3, 1994·The New England Journal of Medicine·G BensimonV Meininger
Aug 1, 1993·The American Journal of Psychiatry·R T JoffeA Levitt
Sep 25, 1995·European Journal of Pharmacology·A BenazzouzC Gross
Sep 21, 1996·Lancet·J Wokke
Jun 1, 1997·The Annals of Pharmacotherapy·M L Wagner, B E Landis
Apr 6, 1999·Journal of Hepatology·A J RemyD Larrey
Jul 31, 1999·Clinical Pharmacokinetics·S N de WildtJ N van den Anker
Jul 25, 2000·British Journal of Pharmacology·T JehleT J Feuerstein
Aug 5, 2000·The Annals of Pharmacotherapy·W A NorthJ R Sporn
Sep 9, 2000·The New England Journal of Medicine·A ViallonJ C Bertrand
Oct 13, 2000·The European Journal of Neuroscience·A Urbani, O Belluzzi
Nov 7, 2000·Biological Psychiatry·W C Drevets
Jul 27, 2001·The American Journal of Gastroenterology·L RodrigoM I Lucena
Oct 26, 2001·Journal of the Neurological Sciences·G J GroeneveldL H van den Berg
Jan 5, 2002·Drug Metabolism Reviews·M B FisherS A Wrighton
Jun 1, 2002·Parkinsonism & Related Disorders·J Jankovic, C Hunter
Jun 14, 2002·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·L LacomblezUNKNOWN ALS Study Groups I and II
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ritsuko Katoh-SembaKanefusa Kato
Dec 12, 2002·Multiple Sclerosis : Clinical and Laboratory Research·N F KalkersC H Polman
Jun 12, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Milena Colovic, Silvio Caccia
Jul 30, 2003·Neuropsychobiology·Adriana Lourenço Da SilvaDiogo R Lara
Sep 5, 2003·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Axel LippJens Jordan
Oct 29, 2003·Neurology·David CassimanWim Robberecht
Jan 2, 2004·The American Journal of Psychiatry·Carlos A ZarateHusseini K Manji
Mar 31, 2004·Cellular and Molecular Neurobiology·Marcos Emílio dos Santos FrizzoDiogo Onofre Souza
Apr 6, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Milena ColovicSilvio Caccia
Apr 16, 2004·Annals of Emergency Medicine·A WoolfD A Tanen

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Citations

Jun 2, 2012·Therapeutics and Clinical Risk Management·Susan L McElroyAnne M O'Melia
Aug 29, 2012·Future Medicinal Chemistry·Jonathan J Cherry, Elliot J Androphy
Oct 24, 2013·Expert Opinion on Drug Discovery·Marco A GradosDiandra Fortune
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Anand GururajanJohn F Cryan
Oct 10, 2012·Neuroscience Letters·Chadi G AbdallahSanjay J Mathew
Oct 4, 2011·Pharmacology & Therapeutics·Christopher PittengerKyle Williams
Jan 12, 2010·Journal of the Neurological Sciences·Farhad GhoddoussiWilliam S A Brusilow
Mar 13, 2014·Depression and Anxiety·Gustavo H VázquezLeonardo Tondo
Mar 26, 2016·European Journal of Medicinal Chemistry·Elisse C Browne, Belinda M Abbott
Apr 9, 2010·Depression and Anxiety·Owen M WolkowitzSynthia H Mellon
Mar 26, 2016·Expert Review of Neurotherapeutics·Liang PengAlexei Verkhratsky
Jul 20, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sarah BiedermannAlexander Sartorius
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenji Hashimoto
Feb 3, 2011·Journal of Biomedical Informatics·Yue W WebsterMathew J Palakal
Aug 5, 2016·Journal of Medicinal Chemistry·Alyssa N CalderKevin J Hodgetts
Dec 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J GrantSusan E Swedo
Jun 15, 2016·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Timo D VloetMichael Simons
Dec 12, 2018·Journal of Psychopharmacology·Mohammad-Hadi FarahzadiShahin Akhondzadeh
Oct 19, 2017·Journal of Clinical Psychopharmacology·Paul GrantSusan Swedo
Jan 9, 2019·Frontiers in Neurology·Débora LanznasterHélène Blasco
May 19, 2020·Depression and Anxiety·A Irem SonmezPaul E Croarkin
Jan 18, 2020·International Journal of Molecular Sciences·Angelica Benavides-SerratoJoseph Gera
May 28, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Eduardo Octaviano PriminiWagner Ferreira Dos Santos
Nov 4, 2020·Expert Opinion on Therapeutic Targets·Panek MałgorzataPilc Andrzej
Nov 26, 2020·Cellular and Molecular Neurobiology·Zhenzhen XuRenshi Xu
Jan 21, 2021·BMC Medicine·Sarah L BoddyChristopher J McDermott
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sahil MalikSanjay Goyal

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