Ring chromosomes in parosteal osteosarcoma contain sequences from 12q13-15: a combined cytogenetic and comparative genomic hybridization study

Genes, Chromosomes & Cancer
J SzymanskaS Knuutila

Abstract

Seven parosteal osteosarcoma (POS) samples, six of which were cytogenetically characterized, were studied by using comparative genomic hybridization (CGH). All samples showed DNA sequence copy number changes (mean, six aberrations/tumor; range, 1-13); gains were more frequent than losses. Gain of 12q13-15 sequences was found in every tumor and correlated with the presence of ring chromosomes. High-level amplification, which was detected in four tumors, was seen only in chromosome 12, with 12q13-14 as the minimal common region. By using chromosome painting, one of the rings of one case was shown to be composed entirely of chromosome 12 material. Together with previous data, our findings show that gain of 12q13-15 sequences is a characteristic feature of POS and that these sequences are contained within the ring chromosomes.

References

Aug 1, 1992·Cancer Genetics and Cytogenetics·J F SinovicJ R Neff
Jan 1, 1988·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ W Gray
Mar 1, 1994·Genes, Chromosomes & Cancer·N MandahlF Mitelman
Apr 1, 1994·Genes, Chromosomes & Cancer·M NilbertN Mandahl
Jul 1, 1993·Cancer Genetics and Cytogenetics·M TarkkanenS Knuutila
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·F MertensS Heim
Apr 1, 1993·Cancer Genetics and Cytogenetics·F PedeutourC Turc-Carel

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Citations

Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·G WeiM Ladanyi
Oct 29, 2002·International Journal of Cancer. Journal International Du Cancer·Toshifumi OzakiChristopher Poremba
Jun 20, 2002·Cancer Genetics and Cytogenetics·Stéphanie StruskiPascale Cornillet-Lefebvre
Jul 30, 2003·Cancer Genetics and Cytogenetics·Avery A Sandberg, Julia A Bridge
Dec 9, 1998·Cancer Genetics and Cytogenetics·D GisselssonN Mandahl
Jul 6, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiko YoshidaHitoshi Tsuda
Feb 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fanny DujardinGonzague de Pinieux
Aug 11, 2010·The American Journal of Surgical Pathology·Akihiko YoshidaHitoshi Tsuda
Nov 8, 2003·BMC Genomics·Maria-athina MilonaAlasdair J Edgar
Jun 17, 2014·Indian Journal of Orthopaedics·Venkatesan Sampath KumarShah Alam Khan
May 3, 2014·Archives of Pathology & Laboratory Medicine·Jen-Fan Hang, Paul Chih-Hsueh Chen
Jan 17, 2002·Genes, Chromosomes & Cancer·David GisselssonNils Mandahl
Jun 17, 2011·Seminars in Diagnostic Pathology·Meera Hameed, Howard Dorfman
Feb 3, 2009·Pathology, Research and Practice·Mai HeMeera Hameed
May 15, 2007·Cancer Genetics and Cytogenetics·Simone dos Santos AguiarSilvia Regina Brandalise
Jan 21, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BousquetA Gomez-Brouchet
Jul 17, 1998·The American Journal of Pathology·G P NielsenD N Louis
Jun 12, 2012·Sarcoma·Jeff W MartinMaria Zielenska
Dec 20, 2011·European Journal of Radiology·F LarousserieD Vanel
Feb 15, 2015·Human Pathology·Alberto RighiFranco Bertoni
Aug 10, 1999·Genes, Chromosomes & Cancer·W V YotovE Levy
Apr 22, 2008·Clinical Orthopaedics and Related Research·Joseph H SchwabCarol D Morris
Jun 9, 1999·British Journal of Cancer·P H RooneyH L McLeod
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Flore Tabareau-DelalandeGonzague de Pinieux
Oct 17, 2014·Nature Reviews. Cancer·Maya KansaraDavid M Thomas
Feb 4, 2012·The American Journal of Surgical Pathology·Akihiko YoshidaTatsuhiro Shibata
May 29, 2004·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·José Antonio López-GuerreroAntonio Llombart-Bosch
Feb 7, 2020·Head and Neck Pathology·Abberly Lott LimbachNicole A Cipriani
Oct 23, 1997·The American Journal of Surgical Pathology·R SciotH Van den Berghe
Aug 16, 2000·Clinical Orthopaedics and Related Research·G GamberiP Picci
Apr 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Brian D RaglandGene P Siegal
Oct 22, 2019·Journal of the Chinese Medical Association : JCMA·Paul Chih-Hsueh ChenWei-Ming Chen
Oct 9, 1998·Skeletal Radiology·M T Flores-CorralF J Martínez-Tello
Oct 2, 2007·Clinical Orthopaedics and Related Research·Alexandre ArkaderJohn H Healey

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