Abstract
The ubiquitin proteasome system (UPS) plays a fundamental role in maintaining the correct balance of protein levels inside all living cells. Degradation of proteins by this pathway is essential for most cellular processes including cell signalling, DNA repair, apoptosis and gene transcription. Any disruption to the system is likely to have severe consequences which may lead to disorders including neurodegeneration and cancer. Ubiquitin protein ligases are a group of UPS proteins of particular importance because these proteins determine targeting specificity via recognition of a 'target' protein and its' subsequent 'tagging' with ubiquitin. The 26S proteasome recognises these mutli-ubiquitylated proteins, allowing the correct protein to be degraded at the correct time and place within each cell. Several types of ubiquitin protein ligase have now been identified, however, the largest group by far are those proteins containing a 'RING' motif. In this review, examples will be given whereby abnormal protein ubiquitylation due to absence or inefficiency of a RING protein ligase is proposed to be a key regulator of the disease process. Ways in which we may be able to reverse these effects or manipulate these proteins to restore functi...Continue Reading
Citations
Mar 31, 2011·Cell Biochemistry and Biophysics·Michael J EddinsBenjamin Nicholson
Dec 1, 2010·Expert Opinion on Drug Discovery·Lyuben TsvetkovKenyon G Daniel
Jan 29, 2016·Journal of Crohn's & Colitis·Qiao YuMinhu Chen
Sep 18, 2014·Gut and Liver·Xing Wei WangDian Chun Fang
Nov 17, 2010·The FEBS Journal·Xianglan JinDahai Zhu
Jan 26, 2012·Cell Adhesion & Migration·Zhi-dong ZhouEng-king Tan
Aug 20, 2010·Nature Reviews. Cancer·Walter Kolch, Andrew Pitt
Jan 22, 2015·PloS One·Roderico AcevedoScott A Showalter
Jul 18, 2012·PloS One·Gilles MaussionGustavo Turecki
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Sylvanne M Daniels, Anne Gatignol
Jan 28, 2015·Annals of the New York Academy of Sciences·Paul J Hagerman, Randi J Hagerman
Jan 1, 2012·Biology·Gavin C SampeyFatah Kashanchi
Sep 25, 2010·Journal of Biomolecular Screening·Jeffrey G MarblestoneBenjamin Nicholson
Sep 10, 2020·Frontiers in Genetics·Hongfang WangBaohua Xu
Jun 23, 2021·Nature Chemical Biology·Shirish ShuklaTomasz Cierpicki
Jan 17, 2020·Molecular Therapy. Nucleic Acids·Qinghui MengDesen Liang