PMID: 11902656Mar 21, 2002Paper

Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents

Il Farmaco
Veronika OpletalováVladimir Buchta

Abstract

Four series of ring substituted (E)-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones were prepared by means of modified Claisen-Schmidt condensation of acetylpyrazines with aromatic aldehydes. The structures were confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The compounds were tested for specific biological properties and some derivatives exhibited photosynthesis-inhibiting, antifungal and antimycobacterial properties. The most pronounced effects were observed with compounds substituted with phenolic groups. Ortho-hydroxyl substituted derivatives were more potent than the corresponding para-hydroxyl substituted analogues.

References

Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·J H Bates
Jul 18, 2000·Journal of Pharmaceutical and Biomedical Analysis·V OpletalováA Patel

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Citations

Mar 24, 2011·Future Medicinal Chemistry·Prem M S ChauhanMoni Sharma
Nov 26, 2011·European Journal of Medicinal Chemistry·M Vijaya Bhaskar ReddyTian-Shung Wu
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Kucerova-ChlupacovaVeronika Opletalova
Nov 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika OpletalovaMarta Kucerova-Chlupacova
Jan 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Kucerova-ChlupacovaVeronika Opletalova
Apr 10, 2015·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Asu Usta, Hacer Taşkıran

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