PMID: 7019293Aug 1, 1981Paper

Rinkel injection therapy: a multicenter controlled study

The Journal of Allergy and Clinical Immunology
S R HirschS H Cohen

Abstract

The American Academy of Allergy sponsored a 2-yr "double blind" multicenter study of the effect of Rinkel injection therapy (RIT) compared with a histamine placebo in subjects with atopic rhinitis. Accumulated data included the symptom, medication, and physical examination scores and specific IgE antibody levels measured by the radioallergosorbent test (RAST). A total of 155 subjects (81 treated, 74 placebo) entered the project from six centers during their respective ragweed, grass, and mountain cedar pollen (from one center) seasons for a total of 11 pollen seasons. The total mean cumulative dose of extract was 18.6 PNU, which is much lower than recommended for standard immunotherapy. With one exception, none of the centers reported a consistent significant difference between the pollen extract-treated and placebo-treated groups in any of the weekly mean scores or the RAST before, during, and after the pollen seasons. For 4 wk after the height of the mountain cedar season the group treated with pollen extract showed a significant decrease in weekly mean symptom and medication scores as compared with the placebo group. The overall comparison of the mean seasonal scores for the entire study, however, showed no significant diffe...Continue Reading

References

Mar 1, 1977·The Journal of Allergy and Clinical Immunology·J S IronsC R Zeiss
Sep 1, 1977·The Journal of Allergy and Clinical Immunology·G J GleichL L Henderson
Feb 1, 1971·The Journal of Clinical Investigation·D A LevyK Ishizaka
Nov 1, 1971·Annals of Internal Medicine·L M LichtensteinW L Winkenwerder
Feb 1, 1973·The Journal of Clinical Investigation·L M LichtensteinB M Hill
Mar 20, 1969·The New England Journal of Medicine·N SadanL M Lichtenstein
Jul 1, 1966·The Journal of Allergy·G A SprecaceH Ziffer
Sep 23, 1965·The New England Journal of Medicine·F C Lowell, W Franklin
Apr 1, 1980·The Journal of Allergy and Clinical Immunology·T E Van MetreM D Valentine
Jan 1, 1963·Archives of Otolaryngology·H J RINKEL
Feb 1, 1963·Archives of Otolaryngology·H J RINKEL

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Citations

Sep 12, 1998·Primary Care· Fawcett WAIV
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MironeC Ortolani
Jul 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M J SchiffS Weindorf
Jun 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R I Williams
Oct 1, 1982·Clinical Allergy·M H Lessof
Mar 1, 1982·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T M Golbert
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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