RIP1, a member of an Arabidopsis protein family, interacts with the protein RARE1 and broadly affects RNA editing.

Proceedings of the National Academy of Sciences of the United States of America
Stephane BentolilaMaureen R Hanson

Abstract

Transcripts of plant organelle genes are modified by cytidine-to-uridine (C-to-U) RNA editing, often changing the encoded amino acid predicted from the DNA sequence. Members of the PLS subclass of the pentatricopeptide repeat (PPR) motif-containing family are site-specific recognition factors for either chloroplast or mitochondrial C targets of editing. However, other than PPR proteins and the cis-elements on the organelle transcripts, no other components of the editing machinery in either organelle have previously been identified. The Arabidopsis chloroplast PPR protein Required for AccD RNA Editing 1 (RARE1) specifies editing of a C in the accD transcript. RARE1 was detected in a complex of >200 kDa. We immunoprecipitated epitope-tagged RARE1, and tandem MS/MS analysis identified a protein of unknown function lacking PPR motifs; we named it RNA-editing factor interacting protein 1 (RIP1). Yeast two-hybrid analysis confirmed RIP1 interaction with RARE1, and RIP1-GFP fusions were found in both chloroplasts and mitochondria. Editing assays for all 34 known Arabidopsis chloroplast targets in a rip1 mutant revealed altered efficiency of 14 editing events. In mitochondria, 266 editing events were found to have reduced efficiency, w...Continue Reading

References

Dec 22, 1989·Science·R HieselA Brennicke
Oct 19, 1989·Nature·P S Covello, M W Gray
Feb 9, 2000·Trends in Biochemical Sciences·I D Small, N Peeters
May 7, 2002·Trends in Plant Science·Mansour KarimiAnn Depicker
Jan 10, 2003·Nucleic Acids Research·Mark L CroweMartin Trick
Aug 24, 2005·The Plant Journal : for Cell and Molecular Biology·Michael TillichRainer M Maier
Jan 31, 2006·The Plant Journal : for Cell and Molecular Biology·Keith W EarleyCraig S Pikaard
Feb 9, 2006·Cellular and Molecular Life Sciences : CMLS·T Shikanai
Jul 4, 2006·Plant Physiology·Tessa M Burch-SmithS P Dinesh-Kumar
Oct 4, 2006·The Journal of Biological Chemistry·Kenji OkudaToshiharu Shikanai
Oct 17, 2006·The Plant Cell·Christian Schmitz-LinneweberAlice Barkan
Dec 13, 2006·The Plant Journal : for Cell and Molecular Biology·Jason D GillmanMaureen R Hanson
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kenji OkudaToshiharu Shikanai
Jun 15, 2007·Genetics·Stéphane BentolilaMaureen R Hanson
Aug 21, 2007·FEBS Letters·Véronique SaloneClaire Lurin
Apr 26, 2008·The Plant Journal : for Cell and Molecular Biology·Tomohiko KazamaKinya Toriyama
Jul 2, 2008·Molecular and Cellular Biology·Susanne BeickAlice Barkan
Jul 23, 2008·The Plant Journal : for Cell and Molecular Biology·Jessica MarionJean-Denis Faure
Jul 29, 2008·The Plant Journal : for Cell and Molecular Biology·Anne-Laure Chateigner-BoutinPatricia León
Nov 14, 2008·Trends in Plant Science·Christian Schmitz-Linneweber, Ian Small
May 19, 2009·Plant Physiology·Wenhe CaiLixin Zhang
Oct 23, 2009·The Plant Journal : for Cell and Molecular Biology·Kenji OkudaToshiharu Shikanai
Nov 19, 2009·The Plant Journal : for Cell and Molecular Biology·Daniil VerbitskiyMizuki Takenaka
Feb 19, 2010·The Plant Journal : for Cell and Molecular Biology·Eiji TasakiMamoru Sugita

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Citations

Oct 16, 2012·Planta·Rhea Stoppel, Jörg Meurer
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Richard G Dorrell, Christopher J Howe
Nov 28, 2013·Annual Review of Genetics·Mizuki TakenakaAxel Brennicke
Nov 10, 2013·PLoS Pathogens·Javier García-AndradePablo Vera
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tao SunStéphane Bentolila
Jan 28, 2014·Trends in Plant Science·Kamel Hammani, Philippe Giegé
Jan 30, 2014·Annual Review of Plant Biology·Alice Barkan, Ian Small
Apr 16, 2014·Mitochondrion·Mizuki TakenakaAxel Brennicke
Mar 26, 2013·FEBS Letters·Hannes RuweDavid B Stern
Mar 29, 2013·Wiley Interdisciplinary Reviews. RNA·Arnaud GermainDavid B Stern
Mar 26, 2013·The Plant Journal : for Cell and Molecular Biology·Anne-Laure Chateigner-BoutinIan Small
Aug 6, 2013·The Plant Journal : for Cell and Molecular Biology·Mareike Schallenberg-RüdingerVolker Knoop
Jan 30, 2014·The Plant Journal : for Cell and Molecular Biology·Yusuke YagiIan Small
Jan 15, 2015·Biochimica Et Biophysica Acta·Toshiharu Shikanai
Aug 13, 2013·Current Opinion in Microbiology·Ian D SmallAleksandra Filipovska
Dec 24, 2013·Molecular Plant·Mizuki Takenaka
Feb 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Fan ZhangRongcheng Lin
May 15, 2013·RNA Biology·Yusuke YagiTakahiro Nakamura
May 3, 2013·RNA Biology·Aleksandra Filipovska, Oliver Rackham
Jun 19, 2013·RNA Biology·Toshiharu Shikanai, Sota Fujii
Mar 25, 2015·Nucleic Acids Research·Xiaowen ShiStéphane Bentolila
Sep 3, 2013·Biochimie·Catherine Colas des Francs-Small, Ian Small
Apr 29, 2014·Frontiers in Plant Science·Nadja BrehmeMizuki Takenaka
Oct 31, 2016·Trends in Plant Science·Tao SunMaureen R Hanson

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