PMID: 9425162Feb 14, 1998Paper

Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons

The Journal of Cell Biology
C M AdamsM J Welsh

Abstract

Drosophila melanogaster has proven to be a good model for understanding the physiology of ion channels. We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits. Expression of RPK generated multimeric Na+ channels that were dominantly activated by a mutation associated with neurodegeneration. Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels. Although PPK did not form channels on its own, it associated with and reduced the current generated by a related human brain Na+ channel. RPK transcripts were abundant in early stage embryos, suggesting a role in development. In contrast, PPK was found in sensory dendrites of a subset of peripheral neurons in late stage embryos and early larvae. In insects, such multiple dendritic neurons play key roles in touch sensation and proprioception and their morphology resembles human mechanosensory free nerve endings. These results suggest that PPK may be a channel subunit involved in mechanosensation.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A G SwickM D Lane
Oct 1, 1991·Developmental Biology·D H RobinsonD J Benos
Oct 5, 1989·Nature·A J Hudspeth
Sep 1, 1983·Developmental Biology·T J Mitchison, J Sedat
Aug 1, 1995·Current Opinion in Neurobiology·M Kernan, C Zuker
Nov 17, 1995·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Apr 1, 1995·Current Biology : CB·J García-AñoverosM Chalfie
May 1, 1995·The American Journal of Physiology·F J McDonaldM J Welsh
Dec 1, 1994·The American Journal of Physiology·C M CanessaB C Rossier
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L HartlE R Lozovskaya
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·N VoilleyP Barbry
Apr 5, 1996·The Journal of Biological Chemistry·M P PriceM J Welsh
Jul 19, 1996·Science·D P Corey, J García-Añoveros
Aug 1, 1996·Current Opinion in Cell Biology·R A North
Jan 1, 1996·Fundamental & Clinical Pharmacology·U RavensT Mewes
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-AñoverosD P Corey
Mar 13, 1997·Nature·R WaldmannM Lazdunski
Jan 1, 1997·Annual Review of Physiology·N Tavernarakis, M Driscoll
Feb 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Rolf Bodmer, Yuh Nung Jan
Jul 1, 1986·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Alain GhysenYuh -Nung Jan

❮ Previous
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Citations

Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I Mano, M Driscoll
Dec 18, 2001·The Journal of Comparative Neurology·W B GrueberJ W Truman
Apr 17, 2007·Pflügers Archiv : European journal of physiology·Maurice J Kernan
Jun 19, 2008·Cell and Tissue Research·Shin KikuchiHaruyuki Tatsumi
Feb 27, 1999·Biophysical Journal·C M AdamsM J Welsh
May 29, 2003·Journal of Insect Physiology·K W. Beyenbach, R Masia
Mar 10, 2001·Respiration Physiology·M J Carr, B J Undem
Apr 23, 2003·Cell·W Daniel TraceySeymour Benzer
Sep 2, 2003·Trends in Neurosciences·Oleg Krishtal
Oct 9, 1999·Neuroscience Letters·G C McCarterJ D Levine
Aug 28, 1998·Current Opinion in Cell Biology·J D Horisberger
May 22, 2003·The International Journal of Biochemistry & Cell Biology·Peter E Shaw, Janice Saxton
Feb 22, 2012·Nature·Sung Eun KimArdem Patapoutian
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Martin Chalfie
Dec 21, 2002·The European Journal of Neuroscience·Ulli Höger, Andrew S French
Oct 4, 2012·The Journal of Biological Chemistry·Nina BoikoBenjamin A Eaton
May 24, 2012·Biological Reviews of the Cambridge Philosophical Society·Thomas D Förster, H Arthur Woods
Feb 12, 2004·Science's STKE : Signal Transduction Knowledge Environment·Sergei Sukharev, David P Corey
Mar 3, 2010·Annual Review of Biophysics·Jóhanna Arnadóttir, Martin Chalfie
Jun 9, 2000·Annual Review of Neuroscience·H A Lester, A Karschin
Jun 9, 2000·Annual Review of Physiology·D Alvarez de la RosaP Zhang
Jan 14, 2003·Annual Review of Physiology·Miriam B Goodman, Erich M Schwarz
Jul 15, 2011·American Journal of Physiology. Renal Physiology·Ossama B Kashlan, Thomas R Kleyman
May 2, 2007·Neural Development·Melissa M RollsChris Q Doe
Mar 3, 2010·PloS One·Yehuda Ben-ShaharMichael J Welsh
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lu HanLaura Bianchi
Jan 1, 2010·Archives of Histology and Cytology·Shin KikuchiHaruyuki Tatsumi
Jan 18, 2014·BMC Neuroscience·Myung-Jun Kim, Wayne A Johnson
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Heping LinClaudio W Pikielny
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lei LiuMichael J Welsh
Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson
Dec 3, 2014·Current Biology : CB·Stephanie E MauthnerW Daniel Tracey
Jun 18, 2014·Journal of Molecular Biology·Stephan Kellenberger, Thomas Grutter
May 25, 2012·Trends in Neurosciences·Bernd Nilius, Eric Honoré
Aug 16, 2011·Trends in Neurosciences·David H Hall, Millet Treinin
Nov 18, 2008·Microscopy Research and Technique·José A VegaJuan M Cobo

❮ Previous
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