Rise in inulin-sensitive B cells during ontogeny can be prematurely stimulated by thymus-dependent and thymus-independent antigens.

Infection and Immunity
R D Shahin, J J Cebra

Abstract

We have shown that the delayed acquisition of competence in expression of an anti-inulin (IN) response by neonatal BALB/c mice is preceded by a natural increase in the frequency of IN-sensitive B cells between 3 to 5 weeks of life. Up until 3 weeks of age, BALB/c mice resemble adult germfree mice in their low frequency of IN-sensitive B cells (1 to 2/10(6) B cells). Thereafter, the population of IN-reactive B cells rises about 10-fold to the young adult level, without deliberate immunization. This naturally expanded population of IN-reactive cells has an isotype profile resembling populations arising after intentional priming with other antigens in that it contained a large proportion of cells which generated clones expressing immunoglobulin G and immunoglobulin A isotypes, often without detectable immunoglobulin M. The late rise in frequency of IN-sensitive precursors could be induced prematurely by deliberate priming at 3 days of age with either the thymus-dependent antigen IN-hemocyanin or the thymus-independent bacterial levan. However, no circulating anti-IN could be detected following this early administration of antigen. Thus, the delayed expression of anti-IN does not reflect an absence of B cells of the appropriate spe...Continue Reading

References

Jun 1, 1976·The Journal of Experimental Medicine·E S Metcalf, N R Klinman
Jan 1, 1977·Immunological Reviews·D E MosierW E Paul
Jul 1, 1976·European Journal of Immunology·J G Howard, C Hale
Jul 11, 1975·The Journal of Experimental Medicine·R LiebermanM Vrana
Feb 1, 1972·The Journal of Experimental Medicine·A R LawtonM D Cooper
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P J GearhartJ J Cebra

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Citations

Jun 30, 1983·Annals of the New York Academy of Sciences·J J CebraR D Shahin
May 1, 1989·Journal of Clinical Immunology·J R McGheeH Kiyono
Jun 1, 1984·Immunological Reviews·C A BonaL J Rubinstein
Nov 18, 2005·European Journal of Gastroenterology & Hepatology·Jonathan E Teitelbaum, W Allan Walker
May 8, 1999·The American Journal of Clinical Nutrition·J J Cebra
Jan 1, 1984·Infection and Immunity·D H SchwartzP C Doherty

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