PMID: 11918518Mar 29, 2002Paper

Risedronate for the prevention of fractures in postmenopausal osteoporosis

The Annals of Pharmacotherapy
Jennifer M Sickels, Chi-Sing Nip

Abstract

To evaluate current scientific literature regarding the efficacy of risedronate in the prevention of vertebral and nonvertebral fractures in women with postmenopausal osteoporosis. Primary research articles were identified by MEDLINE search (1966-May 2001) and through secondary sources. Key search terms were risedronate, postmenopausal osteoporosis, and fractures. Osteoporosis results in a reduction of bone mineral density, increased bone fragility, and increased risk of fractures. The goal of osteoporosis therapy is not only to increase bone mass, but also to reduce the rate of fractures. Risedronate is the newest bisphosphonate to be approved for the prevention and treatment of osteoporosis. An evaluation of clinical trials using risedronate in the treatment of postmenopausal osteoporosis was performed to determine its efficacy at decreasing fracture rates. Risedronate is an effective and safe option for the treatment of postmenopausal osteoporosis. Risedronate significantly decreases the risk of vertebral and nonvertebral fractures in women who have had > or =1 fractures in the past. More studies are warranted to evaluate the efficacy of risedronate in women without preexisting vertebral fractures.

References

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B ClemmesenJ Y Reginster
Mar 12, 1998·The New England Journal of Medicine·R Eastell
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Jun 13, 2001·JAMA : the Journal of the American Medical Association·D J Torgerson, S E Bell-Syer

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Citations

Jul 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael J McKennaArthur G Kristiansen
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Susan RichmanFrederick Naftolin
Jun 3, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ginelle A SchmidtKevin G Moores

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