Abstract
Composite-tissue allotransplantation (CTA) is a new therapeutic modality to reconstruct major tissue defects of the face, larynx, and extremities. Unlike most life-saving organ-transplantation procedures, CTA is considered to improve quality of life. Therefore, the question arises, do the risks posed by the immunosuppression drugs that patients must take to prevent rejection justify the benefits of these procedures? The purpose of this study was to assess the relative risk that individuals are willing to accept in order to receive the benefits of CTA procedures. We used a psychometrically reliable and valid instrument to question two primary populations of individuals: those who live with the risks of immunosuppression, and healthy individuals. The level of risk acceptance for the seven transplant procedures tested (foot, single hand, double hand, larynx, kidney, hemiface, and full face) showed significant differences in research participants' risk acceptance for the different transplant procedures, but no significant differences between groups. Based on these findings, we conclude that certain CTA procedures convey benefits to recipients that are perceived by subjects, including individuals who live with the risks of immunosup...Continue Reading
References
Aug 24, 1994·JAMA : the Journal of the American Medical Association·T M Gill, A R Feinstein
Apr 1, 1996·Medical Decision Making : an International Journal of the Society for Medical Decision Making·P F KrabbeG J Bonsel
Aug 12, 1998·The Journal of Thoracic and Cardiovascular Surgery·C R Bridges
Sep 23, 1998·Head & Neck·V JalukarP J Moran
Apr 28, 1999·Lancet·J M DubernardN S Hakim
Aug 24, 1999·Surgery·J W JonesJ H Barker
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A M de MattosW M Bennett
May 2, 2000·Microsurgery·X RenJ H Barker
Aug 19, 2000·The New England Journal of Medicine·J W JonesW C Breidenbach
Jan 11, 2001·Microsurgery·C G FrancoisJ H Barker
Mar 7, 2001·Lancet·S HettiaratchyW P Lee
Feb 18, 2004·Transplantation·Peter J MorrisN Rumsey
Apr 16, 2004·Transplantation·Shehan HettiaratchyW P Andrew Lee
Apr 28, 2004·Transplantation Proceedings·M VerouxP Veroux
Sep 6, 2005·Clinics in Plastic Surgery·W P Andrew Lee, Vu T Nguyen
Sep 27, 2005·Transplantation Proceedings·M RascenteA Famulari
Citations
Mar 5, 2008·Plastic and Reconstructive Surgery·Dalibor VasilicJohn H Barker
Aug 14, 2013·PloS One·Jung Ho LeeSeok-Goo Cho
Feb 8, 2014·Current Opinion in Organ Transplantation·Martin KumnigAndrea F DiMartini
Mar 29, 2014·Plastic and Reconstructive Surgery·Oren TesslerWilliam G Austen
Nov 19, 2013·Current Reviews in Musculoskeletal Medicine·River M ElliottL Scott Levin
Jun 27, 2008·Annals of Plastic Surgery·John H BarkerJoseph C Banis
Oct 1, 2011·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·J H BarkerJ M Frank
Feb 20, 2016·Aesthetic Plastic Surgery·Rafael DenadaiCassio Eduardo Raposo-Amaral
Feb 19, 2016·Microsurgery·Yigit O TiftikciogluFeng Zhang
Nov 5, 2011·Hand Clinics·Jeff Chang, David W Mathes
Mar 31, 2009·Transplantation Proceedings·J JableckiZ Boratyńska
Jun 25, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Keiichi MuramatsuToshihiko Taguchi
Dec 18, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·H MadaniP E M Butler
Apr 10, 2007·Clinics in Plastic Surgery·John H BarkerJoseph C Banis
Jul 3, 2009·The Laryngoscope·David B HomRavindhra G Elluru
Oct 5, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Brian GanderJohn H Barker
Feb 6, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Michael DiefenbeckGunther O Hofmann
Oct 5, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Anthony RenshawPeter E M Butler
Sep 28, 2006·The Laryngoscope·Christopher C ReynoldsJohn H Barker
Jul 10, 2013·Microsurgery·Hainan ZhuQingfeng Li
Nov 18, 2015·Microsurgery·Christian Andreas RaduThomas Kremer
Oct 16, 2007·International Journal of Surgery·Charles S BrownJohn H Barker
Oct 3, 2014·Archives of Plastic Surgery·Hyun Kyo JoJun Ho Shin
Mar 1, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Christina L KaufmanRosemary Ouseph
Jan 7, 2014·JBJS Reviews·Scott M TintleL Scott Levin
Mar 25, 2016·World Journal of Transplantation·Martin Kumnig, Sheila G Jowsey-Gregoire
Oct 29, 2014·Annals of the Royal College of Surgeons of England·M NassimizadehD Power
Jun 1, 2016·Archives of Craniofacial Surgery·Jun Ho ChoiSam Yong Lee