Risk analysis of leukaemia incidence among people living along the Techa River: a nested case-control study

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
E OstroumovaM M Kossenko

Abstract

Large quantities of radioactive materials released over time from the Mayak nuclear weapons facility caused significant internal and external exposure for people living along the banks of the Techa River (Southern Urals, Russia). We conducted a nested case-control study in the Extended Techa River Cohort to determine whether the risk of leukaemia incidence increased with protracted exposure to ionising radiation or with other non-radiation risk factors. The study included 83 cases identified over 47 years of follow-up and 415 controls matched for sex, age at diagnosis, age (within a 5 year age group), and date of initial residence in the riverside area. External and internal doses have been calculated using the Techa River Dosimetry System 1996 (TRDS96). Conditional logistic regression was used to calculate odds ratios per Gray (OR/Gy) and 95% confidence intervals (95% CI). After excluding cases of chronic lymphoid leukaemia, the OR/Gy of total, external, and internal doses were 4.6 (95% CI: 1.7-12.3), 7.2 (95%CI: 1.7-30.0) and 5.4 (95%CI: 1.1-27.2), respectively. A history of solid tumour, either malignant or benign, before the leukaemia diagnosis was associated with a 2.5-fold increase in the leukaemia risk (95% CI: 1.1-5.9)....Continue Reading

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Citations

Sep 5, 2007·International Journal of Epidemiology·L Yu KrestininaAv Akleyev
Dec 17, 2009·Radiation and Environmental Biophysics·Lyudmila KrestininaAlexander Akleyev
Mar 24, 2010·Radiation and Environmental Biophysics·Richard WakefordMichael F G Murphy
Apr 30, 2009·International Journal of Radiation Biology·Ethel S Gilbert
Sep 9, 2006·Mutation Research·Yuri E DubrovaAlexander V Akleyev
Jun 30, 2015·Radiation Research·F G DavisA V Akleyev
Dec 28, 2007·Radiation Research·J S Puskin
Jan 14, 2009·Radiation Research·Ausrele KesminieneElisabeth Cardis
Dec 17, 2009·Dose-response : a Publication of International Hormesis Society·Jerome S Puskin
Jan 21, 2015·International Journal of Environmental Research and Public Health·Bao-Ming ShenXu Su
Oct 13, 2009·Health Physics·Roy E Shore
Oct 17, 2013·British Journal of Cancer·L Y KrestininaA V Akleyev
Jan 9, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Richard Wakeford
Jun 30, 2016·Health Physics·Dimitry BazykaAnatoly Romanenko

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