PMID: 9636805Jun 24, 1998Paper

Risk and safety of immunotherapy

Allergy
B Rogala

Abstract

The risk and safety of specific immunotherapy (SIT) has been the subject of many well-designed studies since it was introduced. Most authors consider SIT an efficient and safe mode of treatment despite the occurrence of life-threatening anaphylactic reactions. They emphasize the importance of a proper selection of patients as well as the requirement for highly qualified physicians to provide the treatment. Another problem associated with the safety of SIT is the potential enhancement of the synthesis of immune complexes after the treatment. SIT causes a decrease in allergen-specific IgE which is slower in circulating immune complexes than in the serum. No data are available to show that SIT induces immune-complex diseases, in either the immunologic or the clinical sense. As far as anaphylactic reactions are concerned, new alternative methods different from the conventional parenteral mode of delivery seem to be safe. Our increased understanding of the altered functions of the immune system justifies the assumption that the more specific the method of SIT administration, the more effective and safe it is.

References

May 1, 1979·The Journal of Allergy and Clinical Immunology·P F Kohler
May 1, 1979·The Journal of Allergy and Clinical Immunology·W H YangN J Gilmore
Mar 1, 1977·Clinical Allergy·P O CanoJ P Sladowski
Nov 24, 1990·Lancet·D R StanworthS Nayyar
Sep 1, 1990·The Journal of Allergy and Clinical Immunology·J BousquetF B Michel
Apr 1, 1987·The Journal of Allergy and Clinical Immunology·R F LockeyS C Bukantz
May 1, 1995·International Archives of Allergy and Immunology·R L ShieldsP Jardieu
Nov 1, 1994·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·L M DuBuske
Nov 1, 1994·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·J Bousquet, F B Michel
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G D'AmatoM Cazzola
Jan 1, 1995·The Journal of Allergy and Clinical Immunology·D G TinkelmanJ Tunno
Jul 1, 1994·The Journal of Allergy and Clinical Immunology·J Bousquet, F B Michel
May 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J Frew
Jan 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J Bousquet, F B Michel
Sep 1, 1993·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·S M MatloffD K Greineder
Jan 1, 1993·Allergy
Aug 1, 1993·The Journal of Allergy and Clinical Immunology·H S NelsonA Buchmeier
Jan 1, 1993·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·N J Douglas
Jul 5, 1986·British Medical Journal

❮ Previous
Next ❯

Citations

Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T KusunokiS Hosoi
Feb 13, 2001·Allergy·O QuerciaG F Stefanini
Jun 15, 2006·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Eric LeithSusan Waserman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.