PMID: 16645430Apr 29, 2006Paper

Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs

American Journal of Therapeutics
S P JohnsenJ Rungby

Abstract

Old sulphonylureas have been linked with adverse cardiovascular effects; however, data on the clinical implications are sparse. We examined the association between use of sulphonylureas and other antidiabetic drugs and the risk and case fatality rate (CFR) of myocardial infarction (MI) in a population-based case-control and follow-up study, respectively. A total of 6738 cases of first-time MI and 67,374 age- and gender-matched population controls were identified from the Hospital Discharge Registry and the Civil Registration System of North Jutland County, Denmark, in the period 1994 through 2002. Prescriptions for antidiabetic drugs before the index date were retrieved from a prescription database. We estimated odds ratios (ORs) of MI (case-control study) and 30-day CFR (follow-up study) associated with antidiabetic drug use adjusted for possible confounding factors and using nondiabetic subjects as the reference group. The risk of MI appeared higher among users of old sulphonylureas (adjusted OR, 2.07; 95% confidence interval (CI), 1.81-2.37) than among users of new sulphonylureas (adjusted OR, 1.36; 95% CI, 1.01-1.84). The adjusted ORs among users of nonsulphonylurea oral antidiabetic drugs, insulin, and patients with diabet...Continue Reading

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Citations

Oct 1, 2008·Cardiovascular Drugs and Therapy·Yumei YeYochai Birnbaum
Feb 5, 2009·Current Diabetes Reports·Stuart W Zarich
Dec 6, 2006·The New England Journal of Medicine·Steven E KahnUNKNOWN ADOPT Study Group
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Mar 29, 2011·Pharmacoepidemiology and Drug Safety·Henriette Thisted HorsdalJørgen Rungby
Apr 25, 2006·Metabolism: Clinical and Experimental·Henriette ThistedJørgen Rungby
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