Risk and timing of cardiovascular disease after androgen-deprivation therapy in men with prostate cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sean O'FarrellMieke Van Hemelrijck

Abstract

Findings on the association between risk of cardiovascular disease (CVD) and the duration and type of androgen-deprivation therapy (ADT) in men with prostate cancer (PCa) are inconsistent. By using data on filled drug prescriptions in Swedish national health care registers, we investigated the risk of CVD in a cohort of 41,362 men with PCa on ADT compared with an age-matched, PCa-free comparison cohort (n = 187,785) by use of multivariable Cox proportional hazards regression models. From 2006 to 2012, 10,656 men were on antiandrogens (AA), 26,959 were on gonadotropin-releasing hormone (GnRH) agonists, and 3,747 underwent surgical orchiectomy. CVD risk was increased in men on GnRH agonists compared with the comparison cohort (hazard ratio [HR] of incident CVD, 1.21; 95% CI, 1.18 to 1.25; and orchiectomy: HR, 1.16; 95% CI, 1.08 to 1.25). Men with PCa on AA were at decreased risk (HR of incident CVD, 0.87; 95% CI, 0.82 to 0.91). CVD risk was highest during the first 6 months of ADT in men who experienced two or more cardiovascular events before therapy, with an HR of CVD during the first 6 months of GnRH agonist therapy of 1.91 (95% CI, 1.66 to 2.20), an HR of CVD with AA of 1.60 (95% CI, 1.24 to 2.06), and an HR of CVD with orchi...Continue Reading

References

Feb 1, 1989·British Journal of Urology·P HenrikssonS E Johansson
Jun 1, 1987·American Journal of Epidemiology·P Henriksson, S E Johansson
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald E HanksUNKNOWN Radiation Therapy Oncology Group
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Ann W Hsing, Anand P Chokkalingam
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Jul 28, 2007·Cancer·Christopher S SaigalUNKNOWN Urologic Diseases in America Project
Oct 9, 2007·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Oct 11, 2007·Journal of the National Cancer Institute·Henry K TsaiPeter R Carroll
Mar 17, 2009·The Journal of Urology·Philip J Saylor, Matthew R Smith
Jun 13, 2009·Journal of the American College of Cardiology·Edward T H Yeh, Courtney L Bickford
Dec 17, 2009·Journal of the National Cancer Institute·Adriana AlbiniDouglas M Noonan
Jun 23, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mieke Van HemelrijckJan Adolfsson
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·David RobinsonPär Stattin
Oct 11, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elisa Martín-MerinoLuis A García Rodríguez
Nov 17, 2011·BJU International·Paul L NguyenAnthony V D'Amico
Dec 8, 2011·JAMA : the Journal of the American Medical Association·Paul L NguyenToni K Choueiri
May 9, 2012·International Journal of Epidemiology·Mieke Van HemelrijckUNKNOWN NPCR and PCBaSe Sweden
Jun 15, 2012·BJU International·F SchröderT E Keane
Dec 5, 2012·Journal of the National Cancer Institute·Nancy L KeatingMatthew R Smith
Dec 19, 2012·The Journal of Urology·Philip J Saylor, Matthew R Smith

❮ Previous
Next ❯

Citations

Dec 17, 2015·Nature Reviews. Urology·Michel Bolla, Gilles Créhange
Oct 28, 2015·Prostate Cancer and Prostatic Diseases·K MitsuzukaUNKNOWN Michinoku Urological Cancer Study Group
Mar 6, 2016·Urologic Oncology·Kreshnik ZejnullahuRahul Aggarwal
Nov 7, 2015·Current Geriatrics Reports·Kim-Lien NguyenCathy C Lee
Nov 29, 2015·Clinics in Geriatric Medicine·Armin ShahrokniStuart M Lichtman
Mar 28, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G PloussardL Salomon
Jul 4, 2015·European Urology·Adi J Klil-DroriLaurent Azoulay
Apr 27, 2016·Nature Reviews. Urology·Peter Busch ØstergrenMikkel Fode
May 30, 2016·Breast Cancer Research and Treatment·Janice S KwonMark S Carey
Jun 28, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I LatorzeffA Pathak
Oct 27, 2015·BJU International·Sean O'FarrellMieke Van Hemelrijck
Jan 25, 2017·Nature Reviews. Urology·Antonello VecciaOrazio Caffo
Mar 16, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan Pollack, Matthew C Abramowitz
Feb 3, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Saro H ArmenianChun Chao
Mar 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shehzad Basaria
Jan 23, 2018·Expert Review of Clinical Pharmacology·Marco BandiniAlberto Briganti
Oct 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dong-Yi ChenWen-Kuan Huang
Apr 25, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Radwa BarakatCheMyong Ko
Apr 2, 2016·Therapeutic Advances in Urology·Piotr ZarebaJehonathan H Pinthus
Feb 26, 2016·Journal of the American Heart Association·Christian Bo PoulsenJacob Fog Bentzon
Oct 7, 2016·Journal of Korean Medical Science·Jinsung ParkHanjong Ahn
Oct 13, 2018·Journal of Oncology Practice·Dipti GuptaRichard M Steingart
Jan 31, 2019·Cardiovascular Research·Mary BarberJoe-Elie Salem
Nov 23, 2019·International Journal of Clinical Practice·Matt T Rosenberg
Apr 28, 2020·Scandinavian Journal of Urology·Magdalena LyckenAnna Bill-Axelson
May 20, 2020·Current Opinion in Urology·Catalin BastonConstantin Gingu
Jul 15, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Hendrik Van Poppel, Per-Anders Abrahamsson
Jan 4, 2017·Journal of the National Cancer Institute·Nataniel H Lester-CollJames B Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.