Risk and Timing of Tuberculosis Among Close Contacts of Persons with Infectious Tuberculosis

The Journal of Infectious Diseases
Mary R ReichlerTuberculosis Epidemiologic Studies Consortium Task Order 2 Team

Abstract

The risk and timing of tuberculosis among recently exposed close contacts of patients with infectious tuberculosis are not well established. We prospectively enrolled patients ≥15 years of age with culture-confirmed pulmonary tuberculosis and their close contacts at 9 health departments in the United States and Canada. Close contacts were screened and cross-matched with tuberculosis registries to identify those who developed tuberculosis. Tuberculosis was diagnosed in 158 of 4490 contacts (4%) of 718 index patients with tuberculosis. Of tuberculosis cases among contacts, cumulative totals of 81 (51%), 119 (75%), 128 (81%), and 145 (92%) were diagnosed by 1, 3, 6, and 12 months, respectively, after the index patients' diagnosis. Tuberculosis rates among contacts were 2644, 115, 46, 69, and 25 cases per 100000 persons, respectively, in the 5 consecutive years after the index patients' diagnosis. Of the tuberculosis cases among contacts, 121 (77%) were identified by contact investigation and 37 (23%) by tuberculosis registry cross-match. Close contacts to infectious patients with tuberculosis had high rates of tuberculosis, with most disease diagnosed before or within 3 months after the index patient' diagnosis. Contact investigat...Continue Reading

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Citations

Feb 12, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary R ReichlerUNKNOWN Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
May 28, 2020·American Journal of Epidemiology·Yicheng MaLaura F White
Nov 9, 2018·Oxidative Medicine and Cellular Longevity·Madhur D ShastriRonan F O'Toole
Aug 2, 2020·BMC Infectious Diseases·Mary R ReichlerUNKNOWN Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
Aug 28, 2020·Frontiers in Microbiology·Zhen-Yan ChenXiao-Yong Fan
Sep 21, 2019·Emerging Infectious Diseases·Laura A VonnahmeThomas R Navin
Oct 11, 2020·Scientific Reports·Russell C AultJoanne Turner
Aug 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kamila RomanowskiJames C Johnston
Feb 3, 2021·The Journal of Clinical Investigation·W Henry BoomJacqueline M Achkar
Sep 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lena ShahTimothy F Brewer
Apr 24, 2021·The Lancet Infectious Diseases·Katie D DaleJustin T Denholm

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