Risk Assessment and Prediction of Severe or Critical COVID-19 Illness in Older Adults

Clinical Interventions in Aging
Xiao-Yu ZhangLiang Chen

Abstract

This study is to investigate the risk prediction of severe or critical events of COVID-19 in older adults in China and provide the evidence to support the management of older adults with COVID-19. The clinical data of older adults with COVID-19 admitted to the Shanghai Public Health Clinical Center during January 20, 2020 to March 16, 2020 were collected. The possible risk factors of severe or critical illness were investigated with Cox proportional hazards (PH) regression models for univariate and multivariate analyses to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For the prediction indicators, optimum cut-off points were determined by calculating Youden's index. The efficacy of risk prediction of severe or critical illness was examined through the receiver operating characteristic (ROC) curve. A total of 110 older adults with COVID-19 were included, in which 21 (19.1%) patients had severe or critical illness of COVID-19. Multivariable regression analysis showed that CD4 cells and D-dimer were independent risk factors. D-dimer, CD4 cells, and CD cells/D-dimer ratio with cut-off values of 0.65 (mg/L), 268 (cell/µL) and 431 were in the prediction of severe or critical illness of older adults with COVID-19. ...Continue Reading

References

Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·Biochemical and Biophysical Research Communications·Yun ChenZhizhuang Joe Zhao
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 1, 2020·Signal Transduction and Targeted Therapy·Li TanHongming Miao
Apr 1, 2020·The Journal of Infectious Diseases·Fan WangYongxi Zhang
Apr 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Yafei ZhangQiu Zhao
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang
Apr 17, 2020·Signal Transduction and Targeted Therapy·Li TanHongming Miao
Apr 23, 2020·Cell Host & Microbe·Evangelos J Giamarellos-BourboulisAntonia Koutsoukou
Jun 9, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Luigi PalmieriUNKNOWN Italian National Institute of Health COVID-19 Mortality Group
Jul 1, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Omar Yaxmehen Bello-ChavollaLuis Miguel Gutiérrez-Robledo
Jul 21, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Janice L AtkinsDavid Melzer

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Citations

Feb 13, 2021·Frontiers in Medicine·Angelo Zinellu, Arduino A Mangoni
May 22, 2021·Immunity & Ageing : I & a·María C MartínJuan Molina

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