Risk assessment for the harmful effects of UVB radiation on the immunological resistance to infectious diseases

Environmental Health Perspectives
W GoettschH van Loveren

Abstract

Risk assessment comprises four steps: hazard identification, dose-response assessment, exposure assessment, and risk characterization. In this study, the effects of increased ultraviolet B(UVB, 280-315 nm) radiation on immune functions and the immunological resistance to infectious diseases in rats were analyzed according to this strategy. In a parallelogram approach, nonthreshold mathematical methods were used to estimate the risk for the human population after increased exposure to UVB radiation. These data demonstrate, using a worst-case strategy (sensitive individuals, no adaptation), that exposure for approximately 90 min (local noon) at 40 degrees N in July might lead to 50% suppression of specific T-cell mediated responses to Listeria monocytogenes in humans who were not preexposed to UVB (i.e., not adapted). Additionally, a 5% decrease in the thickness of the ozone layer might shorten this exposure time by approximately 2.5%. These data demonstrate that UVB radiation, at doses relevant to outdoor exposure, may affect the specific cellular immune response to Listeria bacteria in humans. Whether this will also lead to a lowered resistance (i.e.,increased pathogenic load) in humans is not known, although it was demonstrate...Continue Reading

References

Oct 1, 1989·Photochemistry and Photobiology·W L Morison
Jan 1, 1988·Immunogenetics·J W Streilein, P R Bergstresser
Mar 16, 1995·European Journal of Pharmacology·J GarssenH Van Loveren
Jan 1, 1995·Photochemistry and Photobiology·F P Noonan, F A Lewis
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·J C NoelG De Dobbeleer
Jun 1, 1994·The British Journal of Dermatology·M NorvalH Van Loveren
Mar 1, 1994·Environmental Health Perspectives·W GoettschH van Loveren
Jan 1, 1994·Immunogenetics·F P Noonan, H A Hoffman
Aug 1, 1993·The Journal of Investigative Dermatology·J W GilmourM Norval
May 1, 1996·Photochemistry and Photobiology·W GoettschH Van Loveren
Aug 1, 1996·Photochemistry and Photobiology·J GarssenH van Loveren

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Citations

Jan 24, 2002·The Journal of Experimental Medicine·Jeffrey P WalterscheidDat X Nghiem
Oct 30, 2008·Journal of Immunotoxicology·Annemarie SleijffersHenk Loveren
Oct 4, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Amr S FawzyJennifer Neo
Nov 17, 2001·The Journal of Investigative Dermatology·D X NghiemS E Ullrich
Feb 6, 2004·Clinical Transplantation·F TermorshuizenH van Loveren
Jun 23, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Miao ZhangMengmeng Wang
May 29, 2002·Journal of Exposure Analysis and Environmental Epidemiology·Fabian TermorshuizenHenk Van Loveren
Jun 1, 2013·Journal of Applied Toxicology : JAT·Jena R WirthPatricia A Fair
Jan 23, 1999·Journal of Photochemistry and Photobiology. B, Biology·J LongstrethJ C van der Leun

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