Risk assessment of carcinogenesis at implantation sites

Plastic and Reconstructive Surgery
K G Brand, I Brand

Abstract

Of the 98 foreign-body or scar-related cancers reported in the literature, over 25 percent have developed within 15 years, and over 50 percent within 25 years. Substantial numbers of various implants have now been in place for 10 to 20 years. Since at least 25 percent of cancer cases should already have occurred, the low number actually observed permits the prediction that the incidence of cancers at implantation sites will remain low. This conclusion is supported by studies on 27 specimens of chronic foreign-body reactions against a variety of implants that had been in situ for 1 to 19 years. Employing a cell-culture technique previously developed for experimental mice, an attempt was made to identify specific precancer cells in the tissues. None were detected, in contrast to foreign-body reactions of mice, in which the incidence of foreign-body tumors is high.

Citations

Jul 27, 1999·Annals of the Rheumatic Diseases·C J SchaeferP H Wooley
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Loren LipworthJoseph K McLaughlin
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Søren FriisJørgen H Olsen
Feb 14, 2012·Journal of Applied Toxicology : JAT·Ioannis PolyzoisStamatios Theocharis
Apr 22, 2006·The Journal of Arthroplasty·Tuomo VisuriPekka Paavolainen
Dec 8, 2007·Facial Plastic Surgery Clinics of North America·Vito C Quatela, Jen Chow
Sep 18, 2008·ANZ Journal of Surgery·Gil StynesMark A Kirkland
May 8, 2001·Journal of Biomedical Materials Research·T NakamuraY Shimizu
May 4, 2001·Plastic and Reconstructive Surgery·S J HoshawL L Perkins
Apr 20, 2006·Journal of the National Cancer Institute·Joseph K McLaughlinOlof Nyren
Jul 26, 2008·Nature Nanotechnology·Michael N Helmus
Apr 1, 1994·Journal of Biomaterials Applications·K G Brand
Apr 1, 1997·Plastic and Reconstructive Surgery·D M DeapenG S Brody
Jul 10, 2002·Veterinary Pathology·I Mikaelian, T L Gross
Dec 27, 2007·Plastic and Reconstructive Surgery·Dennis Deapen
Jan 1, 1994·Journal of Biomedical Materials Research·T NakamuraT Shimamoto
Mar 10, 2006·Plastic and Reconstructive Surgery·Neal HandelJ Arthur Jensen
Apr 1, 1991·Journal of Biomaterials Applications·M SzycherA A Siciliano
Jan 5, 2002·Cancer Investigation·R C Herdman, T J Fahey
May 4, 2006·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·T I VisuriP Paavolainen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.