Risk assessment of consumption of methylchavicol and tarragon: the genotoxic potential in vivo and in vitro

Mutation Research
Fabrice NesslanyDaniel Marzin

Abstract

Methylchavicol (or estragole), a natural flavouring substance present in tarragon, was confirmed as a genotoxic chemical in the in vitro UDS test in cultured rat hepatocytes and in the in vivo UDS test in hepatocytes of exposed rats. Deep-frozen tarragon was clearly less genotoxic than methylchavicol at equivalent dose levels, and desiccated tarragon was negative. Both forms of tarragon tested in vitro have the ability to decrease significantly the genotoxicity of methylchavicol added to the culture medium at concentrations </=10 muM for deep-frozen and </=55 muM for desiccated tarragon. The decrease may be attributed to antimutagenic properties of tarragon leaves and/or to adsorption of methylchavicol, which would decrease its bioavailability. Desiccated tarragon powder was not genotoxic in the in vivo UDS test when administered up to the maximum dose of 6.25 g/kg bw (18.75 mg/kg bw of methylchavicol). In vivo, desiccated tarragon did not show antimutagenic properties, because it did not decrease the genotoxicity of methylchavicol added at high concentrations. Considering the low exposure level at the maximum daily tarragon consumption, the rapid detoxification and excretion in humans and the no-genotoxic-effect-level of methy...Continue Reading

References

Oct 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·V S Chan, J Caldwell
Oct 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S A SangsterR L Smith
Apr 1, 1982·Mutation Research·J Sekizawa, T Shibamoto
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L SmithI G Sipes
Aug 2, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·William J Waddell
Feb 27, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·William J Waddell
Mar 27, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lalitha V IyerCarol E Green
Apr 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suzanne M F JeurissenIvonne M C M Rietjens
Jun 10, 2008·Toxicology and Applied Pharmacology·Ans PuntIvonne M C M Rietjens
May 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ans PuntIvonne M C M Rietjens

❮ Previous
Next ❯

Citations

Jan 17, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ludovic Le HégaratValérie Fessard
Sep 27, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Heibatullah KalantariBela Juhasz
May 27, 2017·Beilstein Journal of Nanotechnology·Michelle Romero-FrancoYoram Cohen
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael SchmiechThomas Simmet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.