Risk assessment of deoxynivalenol in food: concentration limits, exposure and effects

Advances in Experimental Medicine and Biology
Moniek N PietersWout Slob

Abstract

The mycotoxin, deoxynivalenol (DON), is produced world-wide by the Fusarium genus in different cereal crops. We derived a provisional TDI of 1.1 microg/kg body weight (bw) and proposed a concentration limit of 129 microg DON/kg wheat based on this TDI and a high wheat consumption of children. In the period September 1998-January 2000, the average DON concentration in wheat was 446 microg/kg (n = 219) in The Netherlands. During this period, the dietary intake of DON exceeded the provisional TDI, especially in children. Eighty percent of the one-year-olds showed a DON intake above the provisional TDI and 20% of these children exceeded twice the provisional TDI. Our probabilistic effect assessment shows that at these exposure levels, health effects may occur. Suppressive effects on body weights and relative liver weight were estimated at 2.2 and 2.7%. However, the large confidence intervals around these estimates indicated that the magnitudes of these effects are uncertain.

Citations

Jan 24, 2018·Toxins·Maria PapageorgiouThozhukat Sathyapalan
Mar 31, 2009·International Journal of Molecular Sciences·Chenghua HeHaibin Zhang
Oct 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seong-Hwan ParkYuseok Moon
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Hyun Ee OkHyang Sook Chun
Jan 16, 2014·Annual Review of Food Science and Technology·Felicia WuJames J Pestka
Feb 15, 2019·Critical Reviews in Food Science and Nutrition·Sakshi MishraSrikanta Kumar Rath
Jan 12, 2007·Molecular Genetics and Genomics : MGG·Doris LucyshynGerhard Adam
Jan 26, 2006·Archives of Environmental Contamination and Toxicology·M U BegT Saeed

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