PMID: 11313107Apr 21, 2001Paper

Risk assessment of the use of deltamethrin on bednets for the prevention of malaria

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S M BarlowJ Lines

Abstract

Risk assessments covering the use of the pyrethroid, deltamethrin, on bednets for the prevention of malaria have been conducted The toxicity of deltamethrin in humans and animals is reviewed following both dermal and oral exposure. The no-adverse-effect level (NOEL) for exposure via the dermal route was 1000 mg/kg body weight/day. From this an acceptable exposure level (AEL) of 10 mg/kg body weight/day has been derived. The NOEL for exposure via the oral route was 1 mg/kg body weight/day, with exposures above this causing neurotoxic effects in animals. This NOEL has been used to derive margins of safety compared with predicted exposures. While direct skin contact does not seem to cause systemic toxicity in humans, it can cause burning, numbness and tingling of the skin, which is a local effect. This too is taken into account in the risk assessments. The risk assessments cover those treating bednets, on an intermittent or regular basis, the washing of treated nets, sleeping under treated nets (infants, children and adults). Worst case scenarios for each of these situations show that dermal exposures are low (one-tenth or less of the AEL) and the margins of safety for systemic exposure derived from oral data are acceptable, rangi...Continue Reading

References

Jan 1, 1978·General Pharmacology·W Wouters, J van den Bercken
Jul 1, 1979·Journal of Agricultural and Food Chemistry·L O RuzoJ E Casida
Jul 1, 1978·Journal of Agricultural and Food Chemistry·L O RuzoJ E Casida
Jan 1, 1991·International Archives of Occupational and Environmental Health·F S HeP P Yao
Feb 1, 1991·British Journal of Industrial Medicine·S Y ChenQ G Li
Feb 1, 1991·British Journal of Industrial Medicine·Z W ZhangF S He
Jan 1, 1989·Archives of Toxicology·F HeJ Sun
Feb 1, 1988·Ecotoxicology and Environmental Safety·S J WangY R Li
Aug 1, 1988·British Journal of Industrial Medicine·F HeL Liu
Jul 1, 1987·JAPCA·P W Preuss, A M Ehrlich
Sep 23, 1983·Journal of Chromatography·H J Stan, H Goebel
Apr 12, 2000·Medical and Veterinary Entomology·M ZaimN Nakashima
Jul 1, 1987·Environmental Monitoring and Assessment·I AhmadP K Ray

❮ Previous
Next ❯

Citations

Oct 19, 2012·Cell Biochemistry and Biophysics·Manal F Ismail, Hanaa M Mohamed
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J H Kolaczinski, C F Curtis
Sep 22, 2007·Journal of Toxicology and Environmental Health. Part a·Paula A MacedoRyan S Davis
Sep 27, 2005·Toxicological Reviews·Sally M BradberryJ Allister Vale
Jun 3, 2011·The American Journal of Tropical Medicine and Hygiene·Robert K D PetersonJerome J Schleier
Dec 19, 2009·Environmental Health Perspectives·Hindrik Bouwman, Henrik Kylin
Apr 5, 2014·International Journal of Environmental Research and Public Health·Yi HuangTinglin Huang
May 21, 2014·International Journal of Environmental Research and Public Health·Chuanshan YuCanping Pan
Sep 26, 2014·Toxicology International·Poonam SharmaMysra Jan
Dec 3, 2014·BMC Complementary and Alternative Medicine·Mona K GalalMarwa A Ibrahim
Dec 4, 2002·Tropical Medicine & International Health : TM & IH·Willem Takken
Apr 12, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Samah S Oda, Zeynab Kh El-Maddawy
Oct 31, 2015·Critical Reviews in Toxicology·John E DoeMichelle R Embry
Jun 1, 2011·Pest Management Science·Paraskevi AkmoutsouPenelope Mavragani-Tsipidou
Jan 29, 2011·Scandinavian Journal of Immunology·H RehmanS Raisuddin
Apr 6, 2005·Reproductive Toxicology·Kenia M PresibellaPaulo R Dalsenter
Oct 3, 2014·Journal of Agromedicine·Martin Rune HansenVivi Schlünssen
Jul 1, 2005·Environmental Toxicology and Pharmacology·Chansak SuwanchaichindaJutamaad Satayavivad
Oct 19, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F SorgeUNKNOWN Société française de pédiatrie
Apr 26, 2011·Ecotoxicology and Environmental Safety·Saoudi MongiEl Feki Abdelfattah
Aug 18, 2016·Canadian Journal of Physiology and Pharmacology·Anouar FerianiMohamed Salah Allagui
Oct 28, 2016·Environmental Toxicology·Tsung-Cheng ChuehSsu Ching Chen
Apr 20, 2017·Revista Do Instituto De Medicina Tropical De São Paulo·Mohammad Hassan KayediNargess Abdali
Feb 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hasibur RehmanSheikh Raisuddin
Apr 13, 2018·Environmental Health Perspectives·Brenda EskenaziJonathan Chevrier
Dec 21, 2019·Nature Microbiology·Jo Lines

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.