Risk assessment of using off-label morphine sulfate in a population-based retrospective cohort of opioid-dependent patients.

British Journal of Clinical Pharmacology
Célian BertinNicolas Authier

Abstract

Several addictovigilance studies have described the off-label use of morphine sulfate (MS) for nonchronic pain in opioid use disorder (OUD) patients as an alternative to conventional opioid substitution treatments (OSTs). This study primarily sought to compare the incidence of unintentional opioid-related overdose in the year following the prescription initiation in off-label MS users, compared to OST-maintained patients. Sequential cohorts of OUD patients who were regularly dispensed MS, buprenorphine, or methadone, between 1 April 2012 and 31 December 2014, were retrospectively identified using the French nationwide healthcare data system. The incidence of overdoses, deaths, doctor shopping, and complications of a viral, bacterial or thrombotic nature, was compared using the Cox regression method. Overall, 1075, 20 834 and 9778 OUD patients without chronic-pain were included in the MS, buprenorphine, and methadone cohorts, respectively. Overdose incidence was 3.8 (P < .01 [95% confidence interval (CI): 2.1-6.8]) and 2.0 (P = .02 [95%CI: 1.1-3.6]) higher in the MS cohort vs buprenorphine and methadone, respectively. Death incidence was 9.1 (P < .01 [95%CI: 3.2-25.9]) and 3.9 (P < .01 [95%CI: 1.4-10.7]) higher in the MS cohort ...Continue Reading

References

Sep 1, 1992·The Journal of Infection·R P Brettle
Jan 29, 1999·Lancet·J WardR P Mattick
Feb 22, 2001·Addiction·Y ObadiaJ P Moatti
Oct 10, 2002·Infectious Disease Clinics of North America·Allan R Tunkel, Sandeep K Pradhan
Mar 1, 2003·Drug and Alcohol Dependence·Gwenaëlle Vidal-TrecanAlain Boissonnas
Jan 30, 2004·The British Journal of Dermatology·P Del Giudice
Feb 1, 2005·Addiction·Rebecca A JenkinsonMalcolm Dobbin
Jul 25, 2006·Pharmacoepidemiology and Drug Safety·Leonard J PaulozziYongli Xi
Sep 22, 2007·The Clinical Journal of Pain·Nathaniel P KatzRoger Weiss
Sep 27, 2008·Lancet·Bradley M MathersUNKNOWN 2007 Reference Group to the UN on HIV and Injecting Drug Use
Feb 12, 2010·Journal of Managed Care Pharmacy : JMCP·Lance NichollsCharles Ruetsch
Apr 29, 2010·Current HIV/AIDS Reports·Steffanie A Strathdee, Jamila K Stockman
Jan 27, 2011·British Journal of Clinical Pharmacology·Jeremie JeguMaryse Lapeyre-Mestre
Dec 6, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Charles S CornfordFiona Inns
Feb 22, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M Soledad CepedaScott C Henderson
Mar 14, 2012·Medical Care·Gretchen L PeirceJoel Halverson
Jul 13, 2012·The New England Journal of Medicine·Theodore J CiceroHilary L Surratt
Aug 4, 2012·Drug and Alcohol Dependence·Jermaine D JonesSandra D Comer
Dec 21, 2012·The Journal of Pain : Official Journal of the American Pain Society·M Soledad CepedaYingli Yuan
Feb 13, 2013·Journal of Clinical Pharmacology·M Soledad CepedaScott C Henderson
Apr 19, 2013·British Journal of Clinical Pharmacology·Isabelle GiraudonRichard C Dart
Jul 23, 2013·PloS One·Douglas C McDonald, Kenneth E Carlson
Aug 21, 2013·Pharmacoepidemiology and Drug Safety·Huijun HanChin-Shang Li
Jun 13, 2014·American Journal of Public Health·Corey S DavisNabarun Dasgupta
Jul 30, 2014·Journal of Substance Abuse Treatment·Robert HämmigChristian Ruckes
Feb 15, 2015·The Journal of Pain : Official Journal of the American Pain Society·Zhuo YangJoy Melnikow
Apr 30, 2015·Therapeutic Advances in Drug Safety·Kyle SimonBenjamin Tarbell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.