Risk Associated with Cumulative Oral Glucocorticoid Use in Patients with Giant Cell Arteritis in Real-World Databases from the USA and UK

Rheumatology and Therapy
Sara GaleKhaled Sarsour

Abstract

Treatment of giant cell arteritis (GCA) involves immediate initiation of high-dose glucocorticoid therapy with slow tapering of the dose over many months. Chronic exposure to glucocorticoids is associated with serious comorbidities. The objective of this analysis was to determine the glucocorticoid exposure and risk of glucocorticoid-related adverse events (AEs) in real-world patients with GCA. Data from the Truven Healthcare MarketScan® database (from January 1, 2000, to June 30, 2015) and the Clinical Practice Research Datalink (CPRD; from January 1, 1995, to August 31, 2013) were used to retrospectively analyze patients aged ≥ 50 years with GCA in the USA and UK, respectively. Outcomes included oral glucocorticoid use (cumulative prednisone-equivalent exposure), glucocorticoid-related AEs and the association of AE risk with glucocorticoid exposure over 52 weeks. Of the 4804 patients in the US MarketScan database and 3973 patients in the UK CPRD database included, 71.3 and 74.6% were women and mean age was 73.4 and 73.0 years, respectively. Median starting glucocorticoid dose and cumulative glucocorticoid dose at 52 weeks were 20-50 mg/day and 4000-4800 mg, respectively. The most frequent glucocorticoid-related AEs were hyper...Continue Reading

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Citations

Feb 7, 2019·Rheumatology International·Durga Prasanna Misra, Vikas Agarwal
Sep 12, 2020·Rheumatology Advances in Practice·Maira KarabayasNeil Basu
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May 4, 2021·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Arielle MendelChristian Pagnoux
Dec 4, 2021·Frontiers in Medicine·Alfred MahrValérie Devauchelle-Pensec

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Methods Mentioned

BETA
ESR

Software Mentioned

GiACTA
MarketScan

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