Risk-based approach in the revised European Union drinking water legislation: Opportunities for bioanalytical tools

Integrated Environmental Assessment and Management
Milou Ml DingemansAnnemarie van Wezel

Abstract

A plethora of in vitro bioassays are developed in the context of chemical risk assessment and clinical diagnostics to test effects on different biological processes. Such assays can also be implemented in effect-based monitoring (EBM) of (drinking) water quality alongside chemical analyses. Effects-based monitoring can provide insight into risks for the environment and human health associated with exposure to (unknown) complex, low-level mixtures of micropollutants, which fits in the risk-based approach that was recently introduced in the European Drinking Water Directive. Some challenges remain, in particular those related to selection and interpretation of bioassays. For water quality assessment, carcinogenesis, adverse effects on reproduction and development, effects on xenobiotic metabolism, modulation of hormone systems, DNA reactivity, and adaptive stress responses are considered the most relevant toxicological endpoints. An evaluation procedure of the applicability and performance of in vitro bioassays for water quality monitoring, based on existing information, has been developed, which can be expanded with guidelines for experimental evaluations. In addition, a methodology for the interpretation of in vitro monitoring ...Continue Reading

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Citations

Jan 27, 2020·Environmental Science and Pollution Research International·Maria Esther Suarez AlpireDaniel Araki Ribeiro
Jan 9, 2021·Journal of Exposure Science & Environmental Epidemiology·Cristina M VillanuevaJose Muñoz
Jul 31, 2021·The Science of the Total Environment·Lara M SchuijtPaul J Van den Brink
Dec 12, 2019·Analytical Chemistry·Susan D Richardson, Susana Y Kimura

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